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Nucleoside Analog Reverse Transcriptase Inhibitor

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AIDS InfoNet

Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...
Ask the Experts

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Non-nucleoside RT... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can then get inside the cell nucleus and become incorporated into the human cell DNA. The enzyme takes... Read more »

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

Protease Inhibitors... Cause Bone Loss???

Hi... I'm currently taking Reyataz and I just read something about Protease Inhibitors and bone loss... Do they cause bone loss? I already have osteoperosis and have suffered awful compression fractures down my spine and DO NOT need any more...
Sharon Lee, M.D.

Response from Sharon Lee, M.D.

University of Kansas Medical Center
First, always check with your doctor when you read things about your meds. It is important to get accurate info. SOme of the PI's may increase the rate of bone loss, although there are differences among the protease inhibitors (different side... Read more »
Connect With Others

Integrase Inhibitor

Posted by Survivor
I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

another stupid question

Posted by mobieorly123
The last post I did was about a test called the HIV PCR BY RNA test, esmerelda reposted and said that you might get a BLIP on that test.

What exactly is a BLIP Read more »

AbacavirLamivudine to treat HIV infection.

Posted by jenniferdraper
AbacavirLamivudine is used to treat HIV infection. This combination medication is used with other medications. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors. Read more »

Massege for SHANE

Posted by Anonymous, 1 Reply
Shane,
Earlier you mentioned that PCR-DNA after 4 weeks will be 95-99% conclusive, is that applied to all kind of risk and where you have this number from? I'm curious to know as FDA does not recognize it as diagnosis tool.
Thanks


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