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Non-nucleoside Reverse Transcriptase Inhibitors Stop Hiv Production By Binding To

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AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 460 : attachment and fusion inhibitors Fact Sheet 470 : new classes of antiretroviral drugs Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. ...
Ask the Experts

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Non-nucleoside RT... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can then get inside the cell nucleus and become incorporated into the human cell DNA. The enzyme takes... Read more »

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

NNRTI and HIV Binding

Dear Dr,Once NNRTI drugs bind the HIV virus. Will the same HIV virus get released once you stop drugs or does it bind permanently....
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello and thanks for posting.NNRTIs bind non-competitively and reversibly to HIV reverse transcriptase enzyme. So once drug levels fall below critical levels, the enzyme is free to go about replicating HIV.BY... Read more »
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Integrase Inhibitor

Posted by Survivor
I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Rutgers researchers may have stopped HIV

Posted by Anonymous, 7 Replies
Rutgers researchers may have stopped HIV

Associated Press - December 12, 2004


Piscataway, N.J. - Researchers at Rutgers University have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a published... Read more »

AbacavirLamivudine to treat HIV infection.

Posted by jenniferdraper
AbacavirLamivudine is used to treat HIV infection. This combination medication is used with other medications. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors. Read more »