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Mutations In Hiv

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mutated hiv

Posted by Anonymous, 1 Reply
Recently Is that true the fact that exist mutated hiv(can't detect Antibody test)?
If the fact's true.. How should we do?

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HIV mutation lights way to a cure for AIDS

Posted by ashler1977, 1 Reply
Excellent news!

SYDNEY (January 16, 2013) An Australian scientist said Wednesday he had discovered a way to turn the HIV virus against itself in human cells in the laboratory, in an important advance in the quest for an AIDS cure.

David Harrich from... Read more »

mutation

Posted by drnsee, 3 Replies
I'm aware that the HIV virus itself may mutate over time. However, my partner who has had HIV twice as long as I have heard that it actually mutates your own [human] DNA. That it integrates into your system so much that this happens over time.

I'm... Read more »

Mutation?

Posted by Anonymous, 3 Replies
Is it possible to have an undetectable or mutated hiv strain? Possible exposure 8 years ago, -ve elisa and DNA PCR taken in the past 4 months. Tons of symptoms within the last year or so.... candida interigo rash, HPV oral warts, proximal toe nail... Read more »

Mutate

Posted by Anonymous, 1 Reply
I was just wondering if anyone knows what subtypes are know to be circulating in the US and whats there prevelance? Also anyone know why all mutations seem to occur outside the US. Why dont mutations occur in America?

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Ask the Experts

Effects of mutation on HIV detection.

The creation of AIDS vaccine is hindered terribly by the rapid mutation of the virus. Does mutation have the same effect on detection methods such as ELISA, Western blot, in situ hybridization methods etc., Could you suggest any specific journals on...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
You are mixing different assays together. ELISA and western blot measure antibodies. Unlikely that mutations would affect detection of these. In situ hybridization measures certain regions of HIV DNA, and could be affected by one or more mutations.... Read more »

Mutation Test for Anti-HIV Drugs

I recently read (in The Washington Blade) a brief piece about a mutation test that "a few" doctors are using to determine what mutations that HIV already has in patients. I asymptomatic HIV+ man who does a great deal of reading (including...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
You are referring to genotype analysis, which tells you which mutations are present (either in the reverse transcriptase enzyme or the protease enzyme-- they are usually two separate tests). The idea is that by knowing which mutations are present,... Read more »

HIV Mutation

At what point in the HIV life cycle does the mutation occur? Does the mutation occur before the HIV reaches the nucleous or after?...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
The genetic material of HIV is in the form of RNA. Our genes are made from DNA. In order for the virus to be able to complete it's life cycle, it must convert it's RNA gene into a DNA gene. This is done by a protein that the virus... Read more »

HIV mutation K103N and Pulmonary Arterial Hypertension

I was diagnosed with HIV that has the mutation K103N in 2006. My CD4 count remained in the 675 - 800 range and viral load was never above 2.500, most of the time around 80 so I did not start meds. Also, at the time, there were few options for the...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The risk for pulmonary hypertension may be increased by HIV infection . It is unclear whether HIV treatment can improve pulmonary hypertension situation. With only the K103 mutation, you can still be successfully treated in majority of cases with... Read more »
Articles
Henry J. Kaiser Family Foundation

Genetic Variations Might Be Causing Mutations to HIV, Making It Less Potent, Study Says

Genetic variations that might help people newly diagnosed with HIV control their viral loads also could be causing a mutation in the virus that makes it less potent, according to a study published Friday in PLoS Pathogens , Reuters reports. Some... Read more »
Henry J. Kaiser Family Foundation

Amino Acid Mutations in Protein Might Make HIV Vulnerable to Immune System Attack, Study Finds

Mutations found in four amino acids in the protein that surrounds HIV might make the virus vulnerable to the immune system, according to a study published in the January issue of PLoS Medicine , ANI/ Thailand News reports. For the study, Julie... Read more »
TheBodyPRO.com

APOBEC3G/F Mutation Not Responsible for HIV Viremia Control in Most Elite HIV Suppressors

There's nothing like hearing the results of studies directly from those who actually conducted the research. It is these women and men who are transforming HIV treatment and care. In this interview, you'll meet one of these impressive HIV... Read more »
Henry J. Kaiser Family Foundation

HIV's Mutations to Avoid Immune Defenses Can Be Passed to Wider Population, Study Says

HIV can adapt rapidly to evade immune system responses, and these mutations can be passed on in the wider population, according to a study published Thursday in the journal Nature , Reuters reports. Although researchers have known that HIV... Read more »