Mitochondrial Toxicity And Aids

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...

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MITOCHONDRIAL TOXICITY

Anti-HIV drug side effects linked to mitochondrial toxicity have been around for years. It is obvious with the growing incidence and possible role of lipodystrophy. It's a fact that all nukes inhibit cellular DNA polymerase beta and gamma, thus...

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital

This rather a long question so I hope I can respond to all of it.The risk factors for lipoatrophy inlcude disease characteristics (AIDS, low CD4), genetic characteristics (genes which promote the pro-inflammatory cytokine TNF) and both nucs and PIs.... Read more »

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Your vitamin regimen seems reasonable under the circumstances. I am not aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of... Read more »

How is Mitochondrial Toxicity Ruled Out?

Dear Dr. Bob,I have been HIV+ for 17 years, and on Viracept, D4T, 3TC for the past three years. My viral load undetectable, CD4's averaging 900, but I have had severe fatigue for around 9 months. I am often so exhausted that I am afraid of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello Whipped in S.F.,Well, Ill stand by my previous statement, "we have much to learn about how to diagnose and treat mitochondrial toxicity." Is there a way to "conclusively rule it out?" Well, there are ways, but these types... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...

Response from Alvan Fisher, M.D.

Brown University School of Medicine

No, not routinely.Alvan Fisher, M.D.... Read more »

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Toxicity: Your Experiences

Posted by Anonymous

Ok.

I recently tested positive and even though my viral load under 2,000 i have a 389 CD4.

I have been investigating epivir/ziagen and viread..they might be available in a new study on a once daily dosing schedule.

My question is, what do u think about... Read more »

Is gay culture toxic?

Posted by Anonymous, 3 Replies

Everywhere you turn you see images of young, clean shaven, hairless, "buffed" boys gracing the gay mags and movies. Who actually looks like most of these people? All we are given to watch on tv is Will and Grace. They represent like 5% of the entire... Read more »

A Toxic Combination

Posted by Choosing2Liv, 9 Replies

If my dilemma was:

- just dealing with the virus; or

- just suffering with the guilt of cheating on my wife; or

- just the feelings of rejections by those who said they loved me; or

- just the constant blaming, belittlement and bursts of rage from my... Read more »

AIDS research losing its steam

Posted by Anonymous, 3 Replies

Almost twenty years and still no cure or effective treatment (most are too toxic). I think there needs to be a new approach to this mess. What do you think?

Read more »

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