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Mitochondrial Toxicity And Aids

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AIDS InfoNet

Mitochondrial Toxicity

...muscle weakness in people taking AZT. It is probably the cause of "fatty liver" (hepatic steatosis) and high levels of lactic acid that can be caused by all of the nukes. Unfortunately, there is very little research on how much mitochondrial damage each ARV causes to different parts of the body. We also don't know which combinations of drugs cause the most MT. Researchers know how to measure the number of mitochondria in different cells,...
Ask the Experts

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been feeling...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on Truvada + Sustiva has been low (<... Read more »

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of dietary recommendations in that setting please post! KH Read more »

mitochondrial toxicity- what is it

Hi, Im taking 3tc, sustivia, and abacavir. Im experiencing lypo- who isnt it seems. What is mitochondrial toxicity and what caused it.Am I taking any medications which may contribute to it, and if so, some suggestions as to what else I might...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...drugs. None of the drugs you are on are usually considered the worst offenders. The cause of lipodystrophy is thus not clear. Mitochondrial toxicity refers to disruption of the function of mitocondria by drugs such as nucleosides reverse... Read more »

mitochondrial damage

Epivir (lamivudine) has caused severe mitochondrial damage after six years of use. I knew this was happening,but my doctor refused to listen. Now, he wants to eliminate all NRTIs from my regimin. Is that possible? to get by with no NRTI. I want to...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...a well qualified certified HIV specialist should be able to do exactly that! If you are having trouble locating a qualified HIV/AIDS specialist in your area, I suggest you check the American Academy of HIV Medicine's Web site at www.aahivm.org,... Read more »
Articles
The Body

The Dangers of Mitochondrial Toxicity: An Update From the 1st International Workshop on HIV & Aging

...the nucleoside analog class of antiretrovirals, which includes Retrovir (zidovudine, AZT) and Zerit (stavudine, d4T), cause mitochondrial toxicity that is associated with subcutaneous fat loss (lipoatrophy), muscle weakness (myopathy), and... Read more »
Project Inform

Mitochondrial Toxicity and Lactic Acidosis Fact Sheet

...this enzyme synergistically (where 1+1 = more than 2). At least one group of researchers claims d4T is most commonly related to mitochondrial damage in people, though others do not accept this finding. Early results from a small study show that... Read more »
Women Alive

Mitochondrial Toxicity

...gradual break-down of the mitochondria. When the mitochondria stop performing, many illnesses can arise. This is what is called mitochondrial toxicity. Some diseases related to mitochondrial dysfunction are lactic acidosis, neuropathy, muscle... Read more »
Canadian AIDS Treatment Information Exchange

Can Uridine Supplements Protect People With HIV/AIDS From Drug Toxicity?

...needed before researchers can be certain that uridine supplements can help people with HIV/AIDS (PHAs) who have symptoms of mitochondrial toxicity. Studies are also needed to find out how much uridine enters the blood after a person takes... Read more »
Connect With Others

Neropathy

Posted by Anonymous, 2 Replies
Hello! I'm a 40 yro, hispanic gay male that recenly come down with a case of neropathy -nerve and shock through out my 10 toes..Ouch! I have trouble walking because my toes are so numb that I'm scared that they may crack or fall off--being unable to... Read more »

BOYCOTT Project (RED) Auction Sothebys

Posted by Alex1, 2 Replies
...Damien Hirst, Gagosian Gallery, Sotheybys and participating artists donating work for the United Nations Foundation to Support HIV/AIDS Relief Programs in Africa to postpone The (RED) Auction in light of the lethal dangers of ART (anti-retroviral... Read more »

What do you think?

Posted by Anonymous, 2 Replies
...Researchers Find AIDS Drugs Cause T Cell Death in Healthy, HIV Negative Patients! In the June Read more »

World AIDS Day 2006: raising 'HIV/AIDS' Awareness

Posted by Anonymous
...World AIDS Day 2006: Raising 'HIV/AIDS' Awareness We urgently need to raise 'HIV/AIDS' Awareness to stop the epidemic spread of AIDS-related Myths, HIV-related Lies Read more »