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Missed Dose Darunavir

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Get the Facts
Test Positive Aware Network


Common Name: darunavir (formerly TMC114) Brand Name: Prezista Class: HIV protease inhibitor (PI) Standard dose: 800 mg (two 400 mg tablets) once daily for first-time therapy or 600 mg (one 600 mg tablet) twice a day for treatment-experienced adults. All doses must be taken with 100 mg Norvir and food. 75 mg and 150 mg tablets available for children over six, dose based on weight. Take missed dose as soon as possible, but...
Ask the Experts

vl of 500, but 100% adherent.

Hi Joe,Very very worried. I have just had my labs back and viral load has jumped from undetectable (<20) to 500. I am on Darunavir and Truvada. Never missed a dose and always taken after a meal and within a 4 hour time frame. I have slight baseline...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
Michael,I agree with getting a repeat quickly to be sure the result is accurate. Did you have a fever, recent vaccination or infection when the first test was done?Also, I assume you are also taking norvir (ritonavir) which is required for full... Read more »

Missed doses

Dear Doctor,I'm on treatment (Darunavir+ritonavir+truvada+raltegravir)since october '07 and I'm undetectable since december '07. I've never forgotten to take my meds but yesterday night I forgot to take them. In the morning I took the pills as...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
First, you did the right thing to take the full dose as soon as you recognized the lapse.A single missed dose is less likely to lead to drug resistance in people who, like you, have achieved an undetectable viral load, as compared to individuals who... Read more »

Follow up to Dr. McGowan's Answer

Hello Dr. McGowan, Thank you very much for replying to my question. to follow up, could you offer some suggestions on new combos? I ask because my dr doesn't feel comfortable switching me as she worries about what resistance I have. Oh, and yes,...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
Alex,Even if the viral load is below 1000 you can often get a result on the genotype test and that should be attempted (if it has not) to use as a guide.You have been on zerit, epivir and trizivir as your "Nucs". These meds share certain resistance... Read more »

Worrying Symptoms

Dr Boob (:I've been on a boosted PI (Darunavir) and Truvada for a few months now - no real side-effects after the initial couple of weeks. Everything was fine until a few weeks ago - I went to the clinic as I had evidence of some sort of urethral...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hi,The real question is whether you have worrisome symptoms or symptoms from worrying. I'd bet on the latter.Regarding your urethral infection, did you place yourself at risk for an STD? If so, why the lapse in judgement? The STD screening test... Read more »
AIDS InfoNet

Darunavir (Prezista)

What Is Darunavir? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Darunavir? Darunavir is a drug used as part of antiretroviral therapy... Read more »

An Overview of Prezista (Darunavir, TMC114)

dar-UE-na-vir Brand Name: Prezista Other Name(s): TMC 114, TMC114 Drug Class: Protease Inhibitors Darunavir, also known as Prezista or TMC114, is a type of medicine called a protease inhibitor (PI). Darunavir... Read more »
Test Positive Aware Network


Common Name: etravirine Brand Name: Intelence Class: non-nucleoside analogs (also called non-nucleoside reverse transcriptase inhibitors, NNRTIs or non-nukes) Standard dose: Two 100 mg tablets twice daily, with food. Take missed... Read more »
Test Positive Aware Network


Common Name: tipranavir (TPV) Brand Name: Aptivus Class: HIV protease inhibitor (PI) Standard dose: Two 250 mg capsules with two 100 mg capsules of Norvir, both twice daily. Must be taken with Norvir. Oral solution available;... Read more »
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