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Metabolism Of Protease Inhibitors

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Ask the Experts

liver metabolism and protease inhibitors

I have been on Norvir/AZT/3TC for the past 13 months and in that time mycholesterol level has jumped from 89 prior to treatment to 358. Prior to HIV infection, the level neverexceeded 150. My doctor and I are now concerned over this development and...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
High triglycerides (which will make your cholesterol high, too) is quitecommon when you're on protease inhibitors, including ritonavir. In theaverage young adult, it's probably not a big problem, but if (for example)you were an older man... Read more »

Xanax and protease inhibitors

I was diagnosed several years ago with panic disorder and have managed well to keep it under... Read more »

Are there alternatives to protease inhibitors?

After 25 years of low or undetectable viral loads, it went up to about 10,000. My doctor gave me a... Read more »
Articles
Henry J. Kaiser Family Foundation

Protein Accumulation Might Cause Fat Deposits, Other Side Effects in HIV-Positive People Taking Protease Inhibitors, Study Says

Similarities between genetic conditions that cause early aging and side effects experienced by some HIV-positive people when taking protease inhibitors might explain the fat accumulation associated with the drugs, according to a study published... Read more »
U.S. Food and Drug Administration

Protease Inhibitors Backgrounder Table of Contents

TheFood and Drug Administration has approved four proteaseinhibitors, members of a class of antiretrovirals that aregenerally considered to be the most potent therapeutic agents forHIV to date. In order for these drugs to be effective, and... Read more »
AIDS InfoNet

Protease Inhibitors in Development

Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)... Read more »
PWA Coalition Colorado

New HIV Protease Inhibitors

Introduction Benefits of Early Protease Inhibitors Limitations of Early Protease Inhibitors Challenges to Protease Inhibitors: Non-Nucleoside RT Inhibitors The Rise of Boosted PIs Therapeutic Challenges and New Protease Inhibitors New Protease... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »