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Mechanism Of Ritonavir

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Ritonavir (Norvir)

... What Is Ritonavir? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Ritonavir? Ritonavir is a drug used as part of antiretroviral therapy (ART).
Ask the Experts


Hi Doc,I am HIV positive and am also taking warfrin for thrombosis. What effect does warfrin have on my ARV. I realize my CD4 has dropped (not imrpoving) since taking warfrin
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...(NNRTIs).DATA SYNTHESIS: The drugs used in the case reports were limited to 6 antiretroviral agents (efavirenz, nevirapine, lopinavir/ritonavir, nelfinavir, saquinavir, ritonavir). The mechanism of interaction between antiretroviral agents and... Read more »

PI diarrhea

Started boosted lexiva,truvada in March, now UD and good CD4/and percentsDentist put me on clindamycin for what he thought was an infected tooth in May (it wasn't)with immediate diarrhea, tolerable so I completed the regimin. Had continuous diarrhea...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...or antidiarrheal meds. The mechanism of protease inhibitor related loose stools is not clear to me but often related to the ritonavir used as a booster which simply seems to irritate the gut of some patients. KH Read more »

Alternative to Reyataz

Dear Dr. Frascino,I have been on Reyataz with Norvir booster (and Truvada) for 4 months now. The meds are fairly well tolerated (some diarrhea) but within a week my eyes (and to a lesses degree my face) have become yellow. Although I've been told...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation to consider, based on your resistance tests and medication history. A switch from booster Reyataz to Kaletra (lopinavir/ritonavir) or boosted Lexiva (fosamprenavir/ritonavir) could be considered. There are also a number of newer agents to... Read more »

just beginning

my question is of the intitial start on medication, I will begin a regimen of combivir 300mg bidand kelettra 30 mg bid or tid,(for the first 30 days)I heard they are overwhelming to the patient is this true? I would also like to know if this is a...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...are fortunate to have a number of options, including alternative medications of all treatment classes.There are a number of mechanisms to assist with getting medications for those who cannot aford to purchase (nearly everyone) or don't have... Read more »
The Body PRO

The Next Generation of Boosters: Promising Data on Potential Alternatives to Ritonavir

...has been rapid metabolism and clearance from the bloodstream, requiring twice-daily or three-times-daily dosing. The use of ritonavir [RTV, Norvir] as a metabolic inhibitor of protease inhibitors caused a major advance in protease inhibitor-based... Read more »
San Francisco AIDS Foundation

Drug Watch: Two New Pharmacoenhancers Give HAART a Boost

... Introduction How Does Boosting Work? Ritonavir Boosting GS-9350 SPI-452 Future Directions Selected Sources Introduction Clinicians typically try to avoid Read more »
Gay Men's Health Crisis

Antiretroviral Medications in the Pipeline

...(raltegravir, Merck). However, elvitegravir may be dosed once daily when combined with a pharmacokinetic (PK) enhancer (i.e. ritonavir or cobicistat). Elvitegravir is one component of Gilead's "Quad," a 4-in-1 coformulation of elvitegravir,... Read more »
U.S. Centers for Disease Control and Prevention

Researchers Uncover Insulin Resistance Link

...some patients. In mouse studies, researchers at WU's School of Medicine found that the first-generation protease inhibitor ritonavir appears to inhibit a key mechanism known as glucose transporter 4, a protein that transports glucose to cells... Read more »
Connect With Others

Reyataz,Norvir, Kivexa [abacavir/3TC, Epzicom].

Posted by Mondo
...Is there anyone here at the forum taking the following cocktail? I'm taking Reyataz[atazanavir], Norvir [ritonavir] and Kivexa [abacavir/3TC, Epzicom]. I would be interested to know how you are going with it and any problems or side effects Read more »


Posted by Anonymous
...develop, and death ultimately occurs. Adapted with permission from Fauci AS, Pantaleo G, Stanley S, Weissman D. Immunopathogenic mechanisms of HIV infection. Ann Intern Med 1996;124:654-63. Some investigators suggest that persons who are... Read more »

Recreational drugs

Posted by Anonymous, 3 Replies
i am going to be starting meds soon and i was wondering what treatments i should avoid. i occasionally do recreational drugs such as ecstasy, ghb, and special k. what kind of reactions can be deadly? i don't want to tell my doctor about my use of... Read more »


Posted by Anonymous, 1 Reply
...I'm looking to talk with people who are currently taking ritonavir (Norvir) capsules and will be affected by the imminent change to liquid ritonavir. I'm a reporter working on Read more »