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Mechanism And Fidelity Of Hiv Reverse Transcriptase

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AIDS InfoNet

Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...
Ask the Experts

Reverse Transcriptase-Is it only related to retrovirus's?

Good day,I sort of understand how rt works and the mechanism nukes and nonnukes work in it's lifecycle to interupt repliction.I am confused about a few things though.Is rt carried out by an enzyme, and is this enzyme needed by the body to carry...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is not a normal enzyme in the human body. Although the HIV drugs affect the function of this viral enzyme specifically, they are close cousins to the building blocks needed to make DNA by a human cell. We are just beginning to... Read more »

TESTING for reverse transcriptase

Dear Dr. Conway, As this is a forum for managing side effects of HIV treatment, I was wondering if you can just very quickly answer a question. How do you test for the reverse transcriptase enzyme. Where can you go to be tested for it?Thanks a...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
This is an experimental test done for research purposes only, in which a DNA/RNA hetrodimer is exposed to the test sample in question (plasma or cell extract) to see if it acts to extend the DNA (a task that can only be accomplished by a reverse... Read more »

Replication mechanism of HIV

Dear Doctor Holodniy,I'll like to ask what is the mechanism of HIV's replication like? Specifically, for the HIV reverse transcriptase, does it convert single strand RNA template to a single strand DNA? If so, how does this single strand...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
The HIV reverse transcriptase enzyme has reverse transcriptase activity that converts the viral HIV RNA to a single strand copy of HIV DNA as well as having DNA-dependent DNA polymerase activity that copies the single DNA strand into another DNA... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can then get inside the cell nucleus and become incorporated into the human cell DNA. The enzyme takes... Read more »
Connect With Others

CONDOM MECHANICS: MY THEORY WAS WRONG!!

Posted by Anonymous, 3 Replies
I am officially admiting I was WRONG on my belief and theory
THAT HIV CAN EASILY PASS THROUGH A CONDOM, here's why:

I decided to test my little theory, and before I go any further, I must say that ONE CANNOT TRUST VERY MUCH YOU READ ON THE INTERNET,... Read more »

CONDOM MECHANICS

Posted by Anonymous, 2 Replies
There is quite alot of RELIABLE data supporting the fact that HIV is an estimated 40x smaller than that of a latex condom's pore. Unfortunately I do not have the source of that data at my side. However, anyone interested can find this data on the... Read more »

CONDOM Mechanics-REPLY..comments warmly welcomed!!

Posted by Anonymous, 2 Replies
Dear Mr. Dragon-

Well, this is different yet again from your early posts. I thank you for taking the time to clarify your thinking. I think the most critical thing is that HIV is NOT EASILY transmitted through a condom, as you mentioned. This is a... Read more »

reversing lipodystrophy....

Posted by Anonymous, 1 Reply
Positive since 2003 full blown aids. Was on Kaletra and combivir. Reached non-detectable, and cd4 rising as expected. Into 3rd year noticing increase in truncal girth. Waist went from 27in. to 32in of hard solid protruding fat. Arms, legs, face... Read more »