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Long Term Side Effects Of Stavudine

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Get the Facts
The Well Project

Side Effects of HIV Drugs

...unless there are no other options. Lactic Acidosis Lactic Acidosis is a buildup of lactic acid in the blood. It is a rare but serious complication of the nucleoside reverse transcriptase inhibitors (NRTIs) such as Zerit (stavudine or d4T) and Videx (didanosine or ddI). Women (especially pregnant women), overweight people, and those with a long history of NRTI use are more likely to develop lactic acidosis. Lactic acidosis can lead to...
Ask the Experts

Lessening ARV Side Effects

Dear Doctor Holodniy,A pleasant day to you.I've been on HIV first line medication for almost seven months now(I'm taking Lamivudine/Stavudine 7:am and 7:00 pm and Efaverinz at 9:00 pm). I started the theraphy at a CD4 of 253 and so far I feel a...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...to discuss the med choices with your doctor. Although it it is a great HIV med, many doctors have gone away from prescribing stavudine these days, as it can cause a lot of metabolic problems. 3. After 7 months, those general side effects should... Read more »

alternate for d4t

dr young good morning .while answering my question fot alternare to d4t you suggestedpart of azt but doubting whether it can be tolarated in short term .which icould not understand . doctor can elobrate so that i try to raise with my doctor during...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...fatigue-- the street talk says that AZT might have more short term side effects, but fewer long-term side effects than d4t (stavudine). BY Read more »

Concerns about long time Stavudine use in a child

My son was diagnosed with AIDS in 1/20/04. As of 6/2004, he has been on a regimen of Stavudine, Lamuvidine and Kaletra. I am concerned about the long term effects of Stavudine. Are there better combinations? Are we going to be sorry that he stays...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...In adults there has been a unmistakable shift away from using stavudine (Zerit) towards tenofovir (Viread). One of the main reasons for this change is that Viread has a better side effect profile Read more »

Changing Meds due to side effects

My wife and I have been on a regimen of Kaletra+Epivir+Zerit for about a year. Our viral loads are undetectable and CD4 counts at around 280-300. She is doing well on these meds, but I have many bothersome side effects, such as: Stomach...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...Hello and thanks for posting.There has been a consistent trend towards less use of Zerit (stavudine) in favor of Viread (tenofovir) in combination therapy. This change has been driven by greater risk of long-term toxicity associated Read more »
Articles
World Health Organization

New HIV Recommendations to Improve Health, Reduce Infections and Save Lives

...HIV-positive patients, including pregnant women, regardless of symptoms. WHO also recommends that countries phase out the use of Stavudine, or d4T, because of its long-term, irreversible side-effects. Stavudine is still widely used in first-line... Read more »
U.S. Centers for Disease Control and Prevention

New WHO Guidelines Urge Phase-Out of Major HIV Drug

...New HIV/AIDS treatment guidelines announced on Monday by the World Health Organization (WHO) include phasing out the use of stavudine (d4T) due to its side effects. Stavudine has long-term, cumulative and irreversible side effects such as... Read more »
Project Inform

Report from the HAARTland

...Combivir® Glaxo Wellcome ddC zalcitabine Hivid® Hoffman La Roche ddI didanosine Videx® Bristol-Myers Squibb d4T stavudine Zerit® Bristol-Myers Squibb 3TC lamivudine Epivir® Glaxo Wellcome   Nucleotide Analog... Read more »
Test Positive Aware Network

Combivir

...and Retrovir (zidovudine, AZT). Do not take zidovudine (Retrovir), Epivir, Epivir-HBV, Epzicom, Trizivir, Emtriva, Truvada, stavudine (Zerit), or Atripla while taking Combivir, since all or part of these medications are already in Combivir or... Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
...where this will lead, but she is going to go stay with her mother who will "nag" her to take her meds. This does not seem lke a long term solution unless she intends to stay with her mother. The doctors strongly advised her to stay in the... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
...give her one year, without six months. Three young children 12 through five (she is only 26). I don't think he has really considered what this will mean and her self esteem is so low she has just decided that this is the hand that fate dealt her.... Read more »

hic

Posted by Anonymous
...-------------------------------------------------------------------------------- Indinavir (Crixivan) Nelfinavir (Viracept) Ritonavir (Norvir) Saquinavir (Fortovase) Stavudine plus lamivudine Efavirenz (Sustiva) Nevirapine (Viramune) ... Read more »

psychological effects with long-term survivor

Posted by Anonymous, 4 Replies
...like a nightmare that I can't wake up from. For now, I am feeling hopeful again that I can continue to live and the fear is subsiding somewhat. Has anyone else ever been as morbid as this or am I just a misfit. Read more »