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Langerhans Cell And Hiv

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Langerhans cells

Hi Dr WohlI've a bit of a technical question. I read that langerhans cells are involved in the sexual transmission of HIV. Now since these cells are numerous within the skin of your body does this mean that infected blood in contact with skin...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
The skin has a wonderful natural barrier to infections, a hard layer of dead cells. This keeps the bad guys out. Deeper down there are Langerhans cells but their role in HIV is somewhat murky with one study actually finding that these cells block... Read more »

Dendritic cells

I know that DC cells (Langerhans) are found also in the epidermis.Do you think that these epidermal... Read more »

Skin Cells

Dear Doctor:Do skin cells contain HIV? iF you scratched yourself with an instrument minus any... Read more »
Articles
HIV i-Base

Mechanisms for Circumcision to Reduce HIV Transmission in Different Penile Tissue: Target Cell Differences Rather Than Keratinisation

An intensive study looking at the protective impact on adult male circumcision for reducing the risk of sexual HIV transmission suggested new biological mechanisms for protection. This study was presented as an oral presentation by Minh Dinh from... Read more »
Henry J. Kaiser Family Foundation

HIV Kills Brain Cells, Prevents Stem Cell Division, Study Says

HIV kills brain cells and prevents stem cells from dividing and forming new cells, according to a study published Wednesday in the journal Cell Stem Cell , Reuters reports. The damage to cells contributes to HIV-associated dementia, which can... Read more »
Henry J. Kaiser Family Foundation

Resting CD4+ T Cells Have Protection Against HIV, But Protection Fails When Cells Become Active, Study Shows

Resting CD4+ T cells have a "powerful" protein shield that protects them from being invaded by HIV, but the cells lose that protection when they are activated to fight an infection, allowing HIV to enter the cells, according to a paper published on... Read more »
Treatment Action Group

Antiviral Activity of Virus-Specific CD8 T Cells Linked to Rate of CD4 T Cell Decline in HIV Infection

The extent to which virus-specific CD8 T cell responses contribute to control of viral load and prevention of disease progression in HIV infection has long been a subject of conflicting data and controversy. Early tests of the ability of CD8 T cells... Read more »
Connect With Others

See,I told you HIV replicates a cell's DNA TO RNA

Posted by Anonymous, 1 Reply
The below is plagerized from Gallant ( the guru!)
I know that the present antiretroviral medications do not actually kill the virus.
However, if the medications inhibit the virus from reproducing, doesn't the virus die
by... Read more »

T Cells

Posted by Anonymous, 3 Replies
I have consistantly tested negative on several tests over the past two years. However, I keep getting symptoms of hiv and my t cells are lurking around the 400 range. I have more test results comminmg back on feb 4th.

Is there anyone else out there... Read more »

White Blood cell count

Posted by Anonymous
Does anyone know if early HIV infection has any impact on WBC numbers? DO they do up unpon infection or do they down down?????

Read more »