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Lab Abnormalities And Mitochondrial Toxicity

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Get the Facts
AIDS InfoNet

Mitochondrial Toxicity

... What Are Mitochondria? What Is Mitochondrial Toxicity? What Are the Signs of MT? How Do ARVs Cause MT? What's Next? What Are Mitochondria? Mitochondria (my-toe- con' -dree-a) are small "organs" in our cells. They are the cell's power plant. They use oxygen, fat and sugar
Ask the Experts

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been feeling...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on Truvada + Sustiva has been low (<... Read more »

mitochondrial toxicity

if it is thought that some nukes cause mitochondrial toxicities/deficiencies. can these problems interfere with the muscles ability for strenght and growth, ie. the ability to weight train?reason being is that I have had extensive fat loss on my...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There have been some reports of impaired/slowed muscle recovery in the setting of mitochondrial toxicity. In addition, I have cared for some patients who report and have exhibited that phenomenon. It seems to be variable and is often Read more »

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of dietary recommendations in that setting please post! KH Read more »

mitochondrial toxicity- what is it

Hi, Im taking 3tc, sustivia, and abacavir. Im experiencing lypo- who isnt it seems. What is mitochondrial toxicity and what caused it.Am I taking any medications which may contribute to it, and if so, some suggestions as to what else I might...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...drugs. None of the drugs you are on are usually considered the worst offenders. The cause of lipodystrophy is thus not clear. Mitochondrial toxicity refers to disruption of the function of mitocondria by drugs such as nucleosides reverse... Read more »
Articles
Project Inform

Mitochondrial Toxicity and Lactic Acidosis Fact Sheet

...Contents Introduction What Are Mitochondria? How Anti-HIV Drugs Affect Mitochondria What Are the Common Results of Mitochondrial Toxicity? Mitochondrial Toxicity and Lactic Acidosis What Is Fatty Liver? Mitochondrial... Read more »
AIDSinfo

Lactic Acidosis

...measure the blood levels of liver enzymes (proteins made and used by the liver) to determine if your liver is working properly. Mitochondrial toxicity: also referred to as mitochondrial dysfunction. Damage to the mitochondria that can cause... Read more »
AIDSinfo

HIV and Pregnancy

...measure the blood levels of liver enzymes (proteins made and used by the liver) to determine if your liver is working properly. Mitochondrial toxicity: also referred to as mitochondrial dysfunction. Damage to the mitochondria that can cause... Read more »
The Well Project

Lactic Acidosis and HIV/AIDS

...can sometimes cause these problems: Cells make too much lactic acid: NRTIs can damage the mitochondria. This isknown as mitochondrial toxicity. It can cause the mitochondria to have troublemaking energy. Lactic acid is made by cells that... Read more »
Connect With Others

Abnormal pap smear

Posted by Anonymous, 2 Replies
My doctor just informed me that my pap smear was abnormal. Could this be an indication of HIV infection? I possibly had an exposure Feb, tested Neg End of April. Read more »

liver panel abnormal

Posted by Anonymous, 2 Replies
I've been on Combivir and Crixivan for 10 years - no side effects and good numbers. However, my last physical (5-06)indicated I should follow-up with a liver panel in 2 months; it was slightly elevated. When is it time to consider changing meds? Read more »

lab time question

Posted by Anonymous, 1 Reply
...I just had a buch of blood work done for insurance...one of the tests was for HIV. Does anyone know how long the labwork should take? it's been a week and I haven't heard anything, they only call if something is abnormal. Just wondering if a Read more »

Scared - new labs

Posted by dj1979, 3 Replies
...Well, after the holidays I finally get my lab results from mid-December - my CD4 is down to 222. This is down from 403 in September. I am only about 2 years post exposure, Read more »