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Lab Abnormalities And Mitochondrial Toxicity

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AIDS InfoNet

Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...
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How is Mitochondrial Toxicity Ruled Out?

Dear Dr. Bob,I have been HIV+ for 17 years, and on Viracept, D4T, 3TC for the past three years. My viral load undetectable, CD4's averaging 900, but I have had severe fatigue for around 9 months. I am often so exhausted that I am afraid of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello Whipped in S.F.,Well, Ill stand by my previous statement, "we have much to learn about how to diagnose and treat mitochondrial toxicity." Is there a way to "conclusively rule it out?" Well, there are ways, but these types... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...
Alvan Fisher, M.D.

Response from Alvan Fisher, M.D.

Brown University School of Medicine
No, not routinely.Alvan Fisher, M.D.... Read more »

mitochondrial toxicity

I've been hearing a lot lately about mitochondrial toxicity and I know one of the most common signs of MT is muscle weakness. I'm 52 and have been positive for around 10 years. My viral load is 15,000 and my t-cell count 450. I'm not...
Thomas N. Kakuda, Pharm.D.

Response from Thomas N. Kakuda, Pharm.D.

University of Minnesota
Gary,Dysfunctional mitochondria in the muscles can lead to a condition known as "mitochondrial myopathy" which manifests itself as muscle weakness and fatigue. The famous cyclist Greg LeMond retired in 1994 due to this disease.... Read more »

mitochondrial toxicity

Which drugs in the na class(including tenofovir)have the least about of mitochondrial toxcity VS. the most,or are they all pretty much the same?...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for the question. The issue of mitochondrial toxicity has gain a lot of recent attention. It is clear that mitochondrial toxicity is associated with lactic acidosis, pancreatitis, and certain types of muscle injury; there is conjecture... Read more »
Connect With Others

lab time question

Posted by Anonymous, 1 Reply
I just had a buch of blood work done for insurance...one of the tests was for HIV. Does anyone know how long the labwork should take? it's been a week and I haven't heard anything, they only call if something is abnormal. Just wondering if a week... Read more »

Scared - new labs

Posted by dj1979, 3 Replies
Well, after the holidays I finally get my lab results from mid-December - my CD4 is down to 222. This is down from 403 in September. I am only about 2 years post exposure, diagnosed 3/14/06. I am 46, have 2 children, and I'm scared. Anyone know... Read more »

My First Labs: Please Share Your Thoughts

Posted by Anonymous
This site has helped me so much. Please help me work through the following. Those of you who dont mind so many questions. This is all new to me:

I recently tested positive for HIV and I believe the seroconversion happened within a year. I recently... Read more »

New labs - sort of

Posted by dj1979, 4 Replies
Well, I had my second set of labs drawn 7/03/06. Went to my doctor last night, and the CD4 is not back yet. Viral load is falling, down to 15,000 from 43,000 3 months ago. Doctor is pleased with that. Concerned that I am anemic - but I always... Read more »