Integrase Inhibitors Mode Of Action

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Isentress

Brand name: Isentress Generic name: raltegravir, or RAL Class: Integrase inhibitor (integrase strand transfer inhibitor, or INSTI) Manufacturer: Merck and Co., www.isentress.com , (800) 622-4477 AWP: $1,171.31/month Standard Dose: One 400 mg film-coated tablet twice a day, with or without food, with no dietary restrictions. Can be taken by children two years or older. Dosing is based on weight for children 2-11 years old. A new...

Ask the Experts

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

New Integrase inhibitor and lipodystrophy risk

There is a once a day integrase inhibitor with a non-PI booster coming up soon, isn't there? What is the integrase inhibitor called and what class does the booster belong to? Setting aside the relative newness of these drugs (and therefore the...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. The new integrase inhibitor medication is called elvitegravir and the booster is GS 9350. The booster is one of a new class of drugs designed specifically to inhibit the CYP3A liver enzyme system. We already know that... Read more »

Integrase Inhibitor

Dr. Young, I am very interested to hear your thoughts on Integrase Inhibitors. -Do you think they will be successful in developing one? -Do you think it can be potentially used as a monotherapy?-Generally what are your thoughts?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your questions.Inhibitors of HIV integrase have been under investigation for some time, though none are currently in advanced clinical trials. There have been a couple of aborted candidate compounds, one from Merck, another from... Read more »

integrase inhibitor

i know that integrase inhibitor are doing very very well..the results are very impressive given the higly drug resistant popolation studied.I realize that the new integrase drugs reduced the viremia because there are less cell infect ( the virus...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.Integrase inhibitors prevent the incorporation (or integration) of the HIV chromosome into the human (CD4 cell) chromosome. There are several integrase inhibitors in various stages of development. By doing so, it's... Read more »

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Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Today's LA Times Article - Integrase Inhibitors

Posted by Anonymous

Very hopeful! (Despite the sad title.)

http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »

AFRAID..Please help!

Posted by Anonymous, 3 Replies

I unfortunately put myself and my girlfriend in a high risk situation; unprotected three-way with a pro. Dumbest thing I ever did and I will probably end up paying for it for the rest of my life. I deserve to be positive following my drunken... Read more »

New HIV therapy shows promise

Posted by losing_it, 1 Reply

Saw this on cnn today.....

WASHINGTON (AP) -- Researchers may finally be on track to fight the AIDS virus by blocking a long-elusive target, an HIV enzyme called integrase. An experimental drug that inhibits the enzyme helped to keep the infection in... Read more »

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