Integrase Inhibitors Hiv Mechanism Action

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Isentress

Brand name: Isentress Generic name: raltegravir, or RAL Class: Integrase inhibitor (integrase strand transfer inhibitor, or INSTI) Manufacturer: Merck and Co., www.isentress.com , (800) 622-4477 AWP: $1,171.31/month Standard Dose: One 400 mg film-coated tablet twice a day, with or without food, with no dietary restrictions. Can be taken by children two years or older. Dosing is based on weight for children 2-11 years old. A new...

Ask the Experts

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

mechanism of action of fusion inhibitors

how do fusion inhibitor act to treat HIV...

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine

There's a ton of information on thebody.com that describes how fusion inhibitors work. You might want to also check out www.fuzeon.com.If you're more into graphics, check out the video link in this message! It's very cool. <a... Read more »

ls isentress integrase inhibitors the future for hiv meds ???

Hi Dr Henry,l have been taking different hiv meds for the past 8 years, and its not much fun with the side effects of the meds, l am reading about isentress integtase inhibitors and would like to know your opinion, is this the new step in hiv...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Raltegravir is a promising new HIV treatment known as an integrase inhibitor. It has mostly been used in patients with resistant virus in complex regimens where it has performed well. It has to be taken twice a day. So far it appears well tolerated... Read more »

Integrase Inhibitor

Dr. Young, I am very interested to hear your thoughts on Integrase Inhibitors. -Do you think they will be successful in developing one? -Do you think it can be potentially used as a monotherapy?-Generally what are your thoughts?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your questions.Inhibitors of HIV integrase have been under investigation for some time, though none are currently in advanced clinical trials. There have been a couple of aborted candidate compounds, one from Merck, another from... Read more »

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Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Today's LA Times Article - Integrase Inhibitors

Posted by Anonymous

Very hopeful! (Despite the sad title.)

http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »

CONDOM MECHANICS: MY THEORY WAS WRONG!!

Posted by Anonymous, 3 Replies

I am officially admiting I was WRONG on my belief and theory
THAT HIV CAN EASILY PASS THROUGH A CONDOM, here's why:

I decided to test my little theory, and before I go any further, I must say that ONE CANNOT TRUST VERY MUCH YOU READ ON THE INTERNET,... Read more »

CONDOM MECHANICS

Posted by Anonymous, 2 Replies

There is quite alot of RELIABLE data supporting the fact that HIV is an estimated 40x smaller than that of a latex condom's pore. Unfortunately I do not have the source of that data at my side. However, anyone interested can find this data on the... Read more »

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