Integrase Inhibitors Dosages

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Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Today's LA Times Article - Integrase Inhibitors

Posted by Anonymous

Very hopeful! (Despite the sad title.)

http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Fusion Inhibitor News?

Posted by Anonymous

Does anyone know if the fusion inhibitor trials (phase III) are going OK, or where to go for an update? Last I heard 700 patients in 100 countries were in the study for T-20(?)
I went to the Trimeris site and didn't see anything new.

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Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

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Ask the Experts

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

New Integrase inhibitor and lipodystrophy risk

There is a once a day integrase inhibitor with a non-PI booster coming up soon, isn't there? What is the integrase inhibitor called and what class does the booster belong to? Setting aside the relative newness of these drugs (and therefore the...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. The new integrase inhibitor medication is called elvitegravir and the booster is GS 9350. The booster is one of a new class of drugs designed specifically to inhibit the CYP3A liver enzyme system. We already know that... Read more »

Integrase Inhibitor

Dr. Young, I am very interested to hear your thoughts on Integrase Inhibitors. -Do you think they will be successful in developing one? -Do you think it can be potentially used as a monotherapy?-Generally what are your thoughts?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your questions.Inhibitors of HIV integrase have been under investigation for some time, though none are currently in advanced clinical trials. There have been a couple of aborted candidate compounds, one from Merck, another from... Read more »

integrase inhibitor

i know that integrase inhibitor are doing very very well..the results are very impressive given the higly drug resistant popolation studied.I realize that the new integrase drugs reduced the viremia because there are less cell infect ( the virus...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.Integrase inhibitors prevent the incorporation (or integration) of the HIV chromosome into the human (CD4 cell) chromosome. There are several integrase inhibitors in various stages of development. By doing so, it's... Read more »

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Articles

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster City, Calif.-based Gilead Sciences on Wednesday at the 13th Conference on Retroviruses and Opportunistic Infections in Denver reported "surprisingly strong" findings from clinical trials of their... Read more »

Comparing Two Integrase Inhibitors

It was more than a wish that integrase inhibitors became weaponry against HIV. We've waited a long time to get to this point and an even longer time to arrive at the position where we're now studying and comparing two integrase inhibitors.... Read more »

Canadian AIDS Treatment Information Exchange

Integrase Inhibitor '572 Tested Against Raltegravir-Resistant HIV

GlaxoSmithKline (GSK) has licensed an anti-HIV integrase inhibitor discovered by the Shionogi Corporation in Japan. Because of these arrangements, this drug has the complex code name S/GSK1349572 and for now is increasingly referred to simply as... Read more »

GSK572 Integrase Inhibitor Shines In Phase II

S/GSK1349572 -- or GSK572 for short -- is a second-generation integrase inhibitor being developed jointly by Shionogi and ViiV Healthcare. Prior research has shown that it works against HIV with some raltegravir-resistance mutations and has a high... Read more »

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