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Indinavir And Hiv

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AIDSinfo

An Overview of Crixivan (Indinavir)

...sulfate, L-735,524, MK-639, Sulfato de indinavir Drug Class: Protease Inhibitors Indinavir sulfate, also known as Crixivan, is a type of medicine called a protease inhibitor (PI). PIs act by blocking protease, a protein that HIV needs to make more copies of itself. HIV/AIDS-Related Uses Indinavir was approved by the FDA on March 13, 1996, for use with other antiretrovirals in the treatment of HIV infection in adults. This medicine...
Ask the Experts

Indinavir sulfate

Dear Doctor,I have a question about the dose of Indinavir sulfate.According to a book about HIV/AIDs treatment (Published by POZ organization), the dose of Indinavir is 800mg three time a day and they also put a remark on the dose of this medicine...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...Thanks for your post.Indinavir (Crixivan) can be dosed either way-- without ritonavir (Norvir) boosting, the medication is dosed every 8 hours, fasting. Indinavir Read more »

HIV and blood clots as a side effect.

Is there any old or recent research evidence that might link the formation of DVT clots in the legs to HIV antiviral therapies using Crixivan and Combivir? I was just admitted to the hospital after experiencing deep ache/pain in my thigh. A blod...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There is a slight increase in blood clots among some patients on PIs (such as indinavir) though HIV infection itself may predispose to increased clots as well so that is hard to sort out in many/most cases. KH Read more »

Skin breakouts with HIV/AIDS

I have a friend who has the HIV virus. She is approximately 45 years old. Recently she dropped lots of weight. She had not been on any medications until that point. Now she is taking meds but has not gained any weight and her facial skin is...
Judith Feinberg, M.D.

Response from Judith Feinberg, M.D.

University of Cincinnati, College of Medicine
...due to her medications (some skin problems have been associated with indinavir, and some drugs cause rashes, but by and large HIV medicines do not cause major skin problems). However, skin problems such as seborrhea are common in people with HIV... Read more »

Delavirdine interactions with Indinavir and other antiretrovirals.

Hi Dr. Cohen!Bob Frascino spoke to a group of us in Monterey, CA last week and began for the first time to explain why I have remained undetectable for so long(4+ years) on the same five drug regimen even though my dosing schedule was not precise. ...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...that way as well. (I think there's a link from this site...) Because yes -- if DLV impacts p450 -- it will effect not only HIV protease inhibitors, but also any drug that uses the p450 system to be metabolized. By the way -- there are two... Read more »
Articles
The Body PRO

Poster Session 22343: A Phase III, Double-Blind, Placebo-Controlled, Multi-Center Study to Determine the Effectiveness and Tolerability of the Combination of Efavirenz and Indinavir (IDV) versus Indinavir in HIV-1 Infected Patients Receiving Nucleoside Analogue (NRTI) Therapy at 24 Weeks

...8 weeks of experience with nucleoside reverse transcriptase inhibitor (NRTI) therapy compared the three drug combination of IDV plus 2 NRTIs (patient's choice) with the FOUR drug combination of efavirenz, plus IDV and two NRTIs. 180 patients had... Read more »
The Body PRO

Late Breaker No. LB15: Randomized Trial of Abacavir in Combination with Indinavir and Efavirenz in HIV-Infected Patients with NRTI Experience

...placebo. Further randomization occurred for patients with CD4>50 within each ABV group so that they received Efavirenz with indinavir in one of two dose schedules (twice daily or thrice daily indinavir), and was designed to make two comparisons:... Read more »
U.S. Food and Drug Administration

Crixivan (Indinavir) Label Revised -- Not Recommended for HIV-Infected Pregnant Patients

...Pharmacology section of the Crixivan (indinavir) label has been revised to include pharmacokinetic data from a study (PACTG 358) in HIV-infected pregnant women. Results from this study show substantially reduced indinavir concentrations in women... Read more »
Seattle Treatment Education Project

Ritonavir Intensification of Indinavir in People Without Complete HIV Suppression

...copies in 53% (9/17) at week 16, and was less than 400 copies in 59% (10/17) at week 16. Thus, in people with detectable, but low HIV RNA viral loads receiving an IDV-containing regimen, intensification with RTV increased IDV trough levels, and... Read more »
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What do you think?

Posted by Anonymous, 2 Replies
...Researchers Find AIDS Drugs Cause T Cell Death in Healthy, HIV Negative Patients! In the June Read more »

Am I?

Posted by Anonymous, 1 Reply
...working as a consultant at Specialty Labs in Santa Monica, CA, setting up analytic routines for the Human Immunodeficiency Virus (HIV). I knew a lot about setting up analytic routines for anything with nucleic acids in it because I invented the... Read more »

does your feet and bones hurt too??

Posted by Anonymous
...Hello everyone ! I found out 1 year ago that I was HIV Positive.My t-cell was 160 and my viral load was 490,000.00.Now my t-cell is 478 and I'm undectable.I take Read more »

Esquire

Posted by Anonymous, 1 Reply
...who lives in Manhattan, became involved with the Treatment Action Group, which put him in daily touch with the cutting edge of HIV science. As each new drug was discovered, Cox was among those at the front of the line to take it. And he was among... Read more »