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Hydroxyurea Side Effects

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AIDS InfoNet

Hydroxyurea (Hydrea)

What Is Hydroxyurea? Hydroxyurea (Hydrea) is a drug that was tested as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. Hydroxyurea is sometimes referred to as HU. Hydroxyurea was approved for use against cancer. It also works against sickle cell anemia. Hydroxyurea has not been approved by the FDA for use against HIV. Hydroxyurea blocks an enzyme produced by human cells. This enzyme makes building blocks used...
Ask the Experts

Side Effects of hydroxyurea

My dad has been taking hydroxyurea for advanced polycythemia vera. He has phlebotomies every one to two months. Usually his platelet ct. & hematocrit dropped after the phlebotomy. His hydroxyurea dosage was doubled about six months ago. Now his...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Is your dad HIV infected (this forum is specifically for persons who are HIV+ or their docs who are having side effects of either HIV or from treatment). HU can reduce the platelet count when used in the setting of HIV infection. Keith Henry, M.D.... Read more »

Ok to continue with hydroxyurea?

Hello. Is hydroxyurea so bad that its benefit is outweighed by its potential for harm??? My current HIV med regimen is composed of d4t, 3tc, and hydroxyurea. I've been taking this regimen on and off for more than a year. My viral load is...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
Well, another controversy in our field.It is clear the hydroxyurea has a pro and a con. On the pro side, we do have information to show us it can boost the potency of some of our nucleoside antivirals. We just presented a study, for example, of... Read more »

What Magazine had Article on DDI/Hydroxyurea Compo

My Dr. would like to read the article on combining DDI/Hydroxurea. I replaced Fuzeon for this combo and I went undetectable for 1st time..but having side affects.Shortness of breath. Lung/heart tests OK. also on Aptivus/norvir, Viramune, Viread....
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Here is a <a href="" target=_new>link</a> to a ddI/hydroxyurea article that... Read more »

hydroxyurea: friend or foe?

Dr. Young,Dr. Paul Curtis Bellman advocates austerely in favor of further study of hydroxyurea as a potential agent having anti-viral fighting capability. In the article below, this doctor discloses several points that he believes illuminates the...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thank you for making us aware of Dr. Bellman's position.I think that the HU and didanosine (ddI, Videx) story is one of increased toxicity under the circumstance of elevated ddI levels. Others including my own analysis of the Center for... Read more »
Connect With Others


Posted by Anonymous, 2 Replies
I'm looking to hear from someone who has tried this hyroxyurea. My doctor wants me to try it in combination with other drugs. ANyone out there with exprience?

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Dry Mouth

Posted by Anonymous, 1 Reply
Does anyone have a treatment/advice when the combination of ddI and hydroxyurea makes my mouth bone dry and has dropped my blood platelets? Am beginning to find this worrying and uncomfortable. And am a little scared. Please help if you have an idea... Read more »

loooking for a good doctor

Posted by Anonymous
HIV Poz gay man moving to Atlanta looking for a good doc. Six years poz and very healthy; taking two protease inhibitors, an antiviral and hydroxyurea. Wanna make sure the viral load stays undetectable. Any suggestions will be greatly appreciated!

Ra... Read more »

Bristol Myers Squibbs: Videx

Posted by Anonymous, 2 Replies
Stay away from Videx it infected my pancreas and made me diabetic, apprantly it does that to a high percentage of people on it or as I also understand kills another hign percentage of them. What does Bristol Myers Squibbs do? Sell death... Read more »