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Hydroxyurea Dosage

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AIDS InfoNet

Hydroxyurea (Hydrea)

What Is Hydroxyurea? Hydroxyurea (Hydrea) is a drug that was tested as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. Hydroxyurea is sometimes referred to as HU. Hydroxyurea was approved for use against cancer. It also works against sickle cell anemia. Hydroxyurea has not been approved by the FDA for use against HIV. Hydroxyurea blocks an enzyme produced by human cells. This enzyme makes building blocks used...
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Side Effects of hydroxyurea

vera. He has phlebotomies every one to two months. Usually his platelet ct. & hematocrit dropped after the phlebotomy. His hydroxyurea dosage was doubled about six months ago. Now his platelet count drops after phlebotomy but his hematocrit...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Is your dad HIV infected (this forum is specifically for persons who are HIV+ or their docs who are having side effects of either HIV or from treatment). HU can reduce the platelet count when used in the setting of HIV infection. Keith Henry, M.D.... Read more »

Off of Hydroxyurea

My doctor took me off Hydoxyurea and adjusted my dosage of d4t and ddi. I am also taking Fortavase and Norvir boost.My question is that my CD4 t-cell counts rose from 400 to 800 and my CD8 went from 800 to 1500 within three months after being taken...
Brian Boyle, M.D., J.D.

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College
Hydroxyurea does suppress the bone marrow and may significantly hold back CD4+ count rises. Your rise is a little higher than I normally see, but still possible. The CD4+ percentage may be a more reliable indicator of the increase, and I would not... Read more »

contrasting combative strategies (hydroxyurea and IL-2)

Dr. Gerald,I am attaching to you an article that is most interesting. How do you feel about the concept of combining hydroxyurea and IL-2? How many years real-time are we away from seeing this in practice?JodyPositives for Positives Winter...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
My feeling is that combining hydroxyurea and IL-2 is not a good thing and using them together would clearly be in the experimental realm. Hydroxyurea has modest antiretroviral activity and suppresses the immune system to some degree. IL-2... Read more »

Hydroxyurea & children

Is Hydroxyurea now being given to pediatric patients? If so, please tell me is this still experimental? ...
Katherine Luzuriaga, M.D.

Response from Katherine Luzuriaga, M.D.

University of Massachusetts, Medical School
Hydroxyurea has been used in children, but there are few formal studies. A pilot study of hydroxyurea in combination with stavudine and ddI has recently been published (Kline et al, Pilot study of hydroxyurea in human immunodeficiency virus-infected... Read more »
Connect With Others


Posted by Anonymous, 2 Replies
I'm looking to hear from someone who has tried this hyroxyurea. My doctor wants me to try it in combination with other drugs. ANyone out there with exprience?

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Dry Mouth

Posted by Anonymous, 1 Reply
Does anyone have a treatment/advice when the combination of ddI and hydroxyurea makes my mouth bone dry and has dropped my blood platelets? Am beginning to find this worrying and uncomfortable. And am a little scared. Please help if you have an idea... Read more »

loooking for a good doctor

Posted by Anonymous
HIV Poz gay man moving to Atlanta looking for a good doc. Six years poz and very healthy; taking two protease inhibitors, an antiviral and hydroxyurea. Wanna make sure the viral load stays undetectable. Any suggestions will be greatly appreciated!

Ra... Read more »

Bristol Myers Squibbs: Videx

Posted by Anonymous, 2 Replies
Stay away from Videx it infected my pancreas and made me diabetic, apprantly it does that to a high percentage of people on it or as I also understand kills another hign percentage of them. What does Bristol Myers Squibbs do? Sell death... Read more »