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How To Prevent Mitochondrial Toxicity When You Have Hiv

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AIDS InfoNet

Mitochondrial Toxicity

...muscle weakness in people taking AZT. It is probably the cause of "fatty liver" (hepatic steatosis) and high levels of lactic acid that can be caused by all of the nukes. Unfortunately, there is very little research on how much mitochondrial damage each ARV causes to different parts of the body. We also don't know which combinations of drugs cause the most MT. Researchers know how to measure the number of mitochondria in different cells,...
Ask the Experts

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been feeling...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on Truvada + Sustiva has been low (<... Read more »

mitochondrial toxicity- what is it

Hi, Im taking 3tc, sustivia, and abacavir. Im experiencing lypo- who isnt it seems. What is mitochondrial toxicity and what caused it.Am I taking any medications which may contribute to it, and if so, some suggestions as to what else I might...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...intracellular organs that are crucial for cell function and energy generation. No intervention has beens shown to consistentlyh prevent mitochondrial damage (though vitamins B1,B2, vit E, co-enzyme Q, L-carnitine and others have been tried with... Read more »

What can I do to prevent mitochondrial toxicity?

Nelson: I am taking Zerit+Kaletra+Epivir and am very aafraid of this thing I keep hearing about called mitochondrial toxicity. What are the symptoms and what supplements or things can I take to prevent it? I want to get off Zerit but my doctor does...
Nelson Vergel, B.S.Ch.E., M.B.A.

Response from Nelson Vergel, B.S.Ch.E., M.B.A.

Program for Wellness Restoration
...inhibitors of pol gamma, although the other NARTIs exert some influence as well. To date, researchers have not studied the extent of mitochondrial damage when anti-HIV medications are combined, which is standard practice for most individuals... Read more »

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of dietary recommendations in that setting please post! KH Read more »
Articles
The Body

The Dangers of Mitochondrial Toxicity: An Update From the 1st International Workshop on HIV & Aging

...the nucleoside analog class of antiretrovirals, which includes Retrovir (zidovudine, AZT) and Zerit (stavudine, d4T), cause mitochondrial toxicity that is associated with subcutaneous fat loss (lipoatrophy), muscle weakness (myopathy), and... Read more »
Project Inform

Mitochondrial Toxicity and Lactic Acidosis Fact Sheet

...this enzyme synergistically (where 1+1 = more than 2). At least one group of researchers claims d4T is most commonly related to mitochondrial damage in people, though others do not accept this finding. Early results from a small study show that... Read more »
Seattle Treatment Education Project

Mitochondrial Damage

...The topic of mitochondrial damage is gaining more and more press as a potential side effect of anti-HIV medication. Simply put, the mitochondria are the "energy Read more »
The Well Project

Caring for Your Liver if You Have HIV/AIDS

...associated with liver damage. NRTIs can have negative side effects that may lead to liver problems. One such side effect is mitochondrial toxicity. Mitochondria are inside of cells and produce energy by breaking down sugars and fat. At the same... Read more »
Connect With Others

Am I Infected

Posted by delhiguy, 3 Replies
I am 30 YO guy. Worried that I may have got infected. I met this friend of mine on 5th of Dec 2010 which was just a causual meeting after 5 years. After having drinks she started touching me and I got aroused and we end up mating. While in act, she... Read more »

BOYCOTT Project (RED) Auction Sothebys

Posted by Alex1, 2 Replies
...Hirst, Gagosian Gallery, Sotheybys and participating artists donating work for the United Nations Foundation to Support HIV/AIDS Relief Programs in Africa to postpone The (RED) Auction in light of the lethal dangers of ART (anti-retroviral... Read more »

Making a documentary on HIV/AIDS in Af.Americans

Posted by Anonymous, 1 Reply
...students. Our goal is to find out what we can do to make a difference, how we can support the health of those living with HIV and AIDS and also promote prevention. If you are interested, please e-mail me at llafatadow@yahoo.com Read more »

Free video: "Top Ten Myths About HIV/AIDS"

Posted by AIDSvideos
...Hi - This is to announce the beta 1 release of http://www.AIDSvideos.org/, whose mission is to prevent the spread of HIV and to assist those affected by making all the world's HIV/AIDS educational Read more »