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How To Prevent Mitochondrial Toxicity When You Have Hiv

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...
Ask the Experts

What can I do to prevent mitochondrial toxicity?

Nelson: I am taking Zerit+Kaletra+Epivir and am very aafraid of this thing I keep hearing about called mitochondrial toxicity. What are the symptoms and what supplements or things can I take to prevent it? I want to get off Zerit but my doctor does...
Nelson Vergel, B.S.Ch.E., M.B.A.

Response from Nelson Vergel, B.S.Ch.E., M.B.A.

Program for Wellness Restoration
I wish there was a clear answer to your question. As you probably remember from your biology class in school, the mitocondria are tiny cells within a cell that produce energy as ATP from sugars and fats. It seems that nucleoside analogs (NRTIs) not... Read more »

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Clinical assessment as well as venous lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on... Read more »

mitochondrial toxicity- what is it

Hi, Im taking 3tc, sustivia, and abacavir. Im experiencing lypo- who isnt it seems. What is mitochondrial toxicity and what caused it.Am I taking any medications which may contribute to it, and if so, some suggestions as to what else I might...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Lipodystrophy is not precisely defined but includes issues related to fat distribution (too much in some areas and loss of fat in others) and increases in blood fat levels. Some of those conditions are seen in the general population. Lipodystrophy... Read more »

MITOCHONDRIAL TOXICITY

Anti-HIV drug side effects linked to mitochondrial toxicity have been around for years. It is obvious with the growing incidence and possible role of lipodystrophy. It's a fact that all nukes inhibit cellular DNA polymerase beta and gamma, thus...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
This rather a long question so I hope I can respond to all of it.The risk factors for lipoatrophy inlcude disease characteristics (AIDS, low CD4), genetic characteristics (genes which promote the pro-inflammatory cytokine TNF) and both nucs and PIs.... Read more »
Connect With Others

A Toxic Combination

Posted by Choosing2Liv, 9 Replies
If my dilemma was:

- just dealing with the virus; or

- just suffering with the guilt of cheating on my wife; or

- just the feelings of rejections by those who said they loved me; or

- just the constant blaming, belittlement and bursts of rage from my... Read more »

Preventing the increasing rate of HIV infections

Posted by PeaceandLove, 3 Replies
So Ive been thinking about this for awhile and wanted to post this but wasnt sure if I should, but after reading an article today that I noticed on CNN, I thought it was a sign that I should post it. The article was basically about how HIV... Read more »

HIV Prevention Job Oppotunities In LA

Posted by Anonymous
Entry level HIV Prevention job opportunities in Los Angeles. Seeking energetic individuals for outreach workers and prevention case managers.

Please visit www.thewallasmemorias.org

Read more »

Bush ignores HIV prevention methods that work

Posted by bradford, 2 Replies
U.S. President George Bush ignores HIV prevention methods that work!
Who is informing the president on HIV and AIDS?

Failure of the American president to recognize the need to promote condoms has not only undermined over two decades of HIV prevention... Read more »