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How To Identify Mitochondrial Toxicity

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AIDS InfoNet

Mitochondrial Toxicity

...muscle weakness in people taking AZT. It is probably the cause of "fatty liver" (hepatic steatosis) and high levels of lactic acid that can be caused by all of the nukes. Unfortunately, there is very little research on how much mitochondrial damage each ARV causes to different parts of the body. We also don't know which combinations of drugs cause the most MT. Researchers know how to measure the number of mitochondria in different cells,...
Ask the Experts

How is Mitochondrial Toxicity Ruled Out?

Dear Dr. Bob,I have been HIV+ for 17 years, and on Viracept, D4T, 3TC for the past three years. My viral load undetectable, CD4's averaging 900, but I have had severe fatigue for around 9 months. I am often so exhausted that I am afraid of falling....
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hello Whipped in S.F.,Well, Ill stand by my previous statement, "we have much to learn about how to diagnose and treat mitochondrial toxicity." Is there a way to "conclusively rule it out?" Well, there are ways, but these types of tests are not... Read more »

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been feeling...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on Truvada + Sustiva has been low (<... Read more »

mitochondrial toxicity

if it is thought that some nukes cause mitochondrial toxicities/deficiencies. can these problems interfere with the muscles ability for strenght and growth, ie. the ability to weight train?reason being is that I have had extensive fat loss on my...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There have been some reports of impaired/slowed muscle recovery in the setting of mitochondrial toxicity. In addition, I have cared for some patients who report and have exhibited that phenomenon. It seems to be variable and is often Read more »

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of dietary recommendations in that setting please post! KH Read more »
Articles
Seattle Treatment Education Project

Mitochondrial Damage

...The topic of mitochondrial damage is gaining more and more press as a potential side effect of anti-HIV medication. Simply put, the mitochondria are the "energy Read more »
The Body

The Dangers of Mitochondrial Toxicity: An Update From the 1st International Workshop on HIV & Aging

...the nucleoside analog class of antiretrovirals, which includes Retrovir (zidovudine, AZT) and Zerit (stavudine, d4T), cause mitochondrial toxicity that is associated with subcutaneous fat loss (lipoatrophy), muscle weakness (myopathy), and... Read more »
AIDS InfoNet

Stavudine (Zerit)

...energy production by the cells. It may be caused by damage to the mitochondria. See Fact Sheet 556 for more information on mitochondrial toxicity. Lactic acidosis can cause severe damage to the pancreas and liver. Symptoms of lactic acidosis... Read more »
AIDS InfoNet

Didanosine (Videx, ddI)

...energy production by the cells. It may be caused by damage to the mitochondria. See Fact Sheet 556 for more information on mitochondrial toxicity. Lactic acidosis can cause severe damage to the pancreas and liver. Symptoms of lactic acidosis... Read more »
Connect With Others

Researchers identify promising agents for HIV cure

Posted by optimistic2009
...Researchers from the University of North Carolina and Merck are identifying promising new leads in the search for agents that may be able to purge HIV from resting CD4 cells, a key requirement for any Read more »

Scientists Identify Gene That Blocks HIV

Posted by Mssimone, 1 Reply
...Is this a good thing? Scientists Identify Gene That Blocks HIV American and Canadian researchers have identified a human gene called TRIM22 that can block HIV infection by preventing certain forms of the virus from replicating, CBC News... Read more »

A Toxic Combination

Posted by Choosing2Liv, 9 Replies
If my dilemma was: - just dealing with the virus; or - just suffering with the guilt of cheating on my wife; or - just the feelings of rejections by those who said they loved me; or - just the constant blaming, belittlement and bursts of rage... Read more »

group N difficult to be identified!

Posted by Anonymous, 1 Reply
...SIVcpz strains. Specimens with reactivity to group N and SIVcpz antigens were characterized by RT-PCR and sequence analysis to identify the infecting virus. Although several specimens were serotyped as potential group N or SIVcpz infections, only... Read more »