How To Identify Mitochondrial Toxicity

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...

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How is Mitochondrial Toxicity Ruled Out?

Dear Dr. Bob,I have been HIV+ for 17 years, and on Viracept, D4T, 3TC for the past three years. My viral load undetectable, CD4's averaging 900, but I have had severe fatigue for around 9 months. I am often so exhausted that I am afraid of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello Whipped in S.F.,Well, Ill stand by my previous statement, "we have much to learn about how to diagnose and treat mitochondrial toxicity." Is there a way to "conclusively rule it out?" Well, there are ways, but these types... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...

Response from Alvan Fisher, M.D.

Brown University School of Medicine

No, not routinely.Alvan Fisher, M.D.... Read more »

mitochondrial toxicity

I've been hearing a lot lately about mitochondrial toxicity and I know one of the most common signs of MT is muscle weakness. I'm 52 and have been positive for around 10 years. My viral load is 15,000 and my t-cell count 450. I'm not...

Response from Thomas N. Kakuda, Pharm.D.

University of Minnesota

Gary,Dysfunctional mitochondria in the muscles can lead to a condition known as "mitochondrial myopathy" which manifests itself as muscle weakness and fatigue. The famous cyclist Greg LeMond retired in 1994 due to this disease.... Read more »

mitochondrial toxicity

Which drugs in the na class(including tenofovir)have the least about of mitochondrial toxcity VS. the most,or are they all pretty much the same?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for the question. The issue of mitochondrial toxicity has gain a lot of recent attention. It is clear that mitochondrial toxicity is associated with lactic acidosis, pancreatitis, and certain types of muscle injury; there is conjecture... Read more »

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