How Often Do You Have To Take NNRTIs

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Know Your HIV Drugs: NNRTIs

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs are another class of FDA-approved HIV antiviral drugs. There are currently three drugs approved for use in this class. NNRTIs work by targeting the structure of reverse transcriptase... Read more »

Drug Watch: Next-Generation NNRTIs: Etravirine and Rilpivirine

Why Do We Need More NNRTIs? Leading the Next Generation: Etravirine and Rilpivirine Etravirine: The DUET Studies Rilpivirine Implications for Treatment Selected Sources Even in patients with the most resistant virus, our goal now is full... Read more »

NNRTIs: The Next Generation Approaches

Part I Introduction Mechanisms of NNRTI Activity and HIV NNRTI Resistance NNRTI Resistance in NNRTI-Naive and NNRTI-Experienced Individuals NNRTI Mutations: Resistance and Cross-Resistance NRTI Mutations: The Potential Impact on NNRTIs NNRTI... Read more »

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Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation at codon 106 in HIV-1 clade C viruses that occurs after exposure to efavirenz appears to result in high-level resistance to other non-nucleotide...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for pointing out the research.So far, this does not seem like a very common issue-- however, a different mutation at codon 103 is commonly found among persons with clade B HIV (the US, Western Europe flavor)- this mutation usually causes high... Read more »

NNRTIs and lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've been on Sustiva/Truvada for 14 weeks with great results but have been battling high cholesterol for about 10 years, HDL high, LDL low, well controlled...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Lipitor and other statins are not on the absolutely contraindicated list on the FDA approved package insert for sustiva. With anything you just need to be careful and have close followup.... Read more »

Questions never answered

Hello, I am allergic to Viramune so I cannot take NNRTIs. I am not resistant to any medications. My doctor recently prescribed Norvir, Reyataz, and Truvada. Is this a good regimen given that I cannot take NNRTIs? Thank you. ...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello and thanks for your post.If you're allergic to nevirapine, it's certainly possible to take other first-line treatments. Indeed, the regimen that your doctor has prescribed is one of the most commonly used, first-line regimens in the... Read more »

Low load confuses resistance tests ?

I have been HIV + for 10 years, no PIs just NNRTIs so far.Never had a detectable viral load (since 94). T cells etc are stable at about 750 ratios good. I have had blood cultures that cannot culture virus within the last two years. Just to...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

I assume that undetectable for you is < 400 copies/ml and not <50/ml, in which case it is technically possible to find enough plasma RNA to do resistance testing. In those with < 50/ml, it is extremely difficult. Certain mutations in the... Read more »

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Lab, med change, confusion

Posted by kaplan08, 2 Replies

Labs of last year have shown a vload range between <400 and 793, with <400 being most recent; CD4 percentage range from 31% to 34%, with 33% being most recent. Taking only Viramune and Combivir -a test has recently shown resistance to... Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Re: Something uplifting

Posted by SA_Intellect, 3 Replies

The link below is the response one of the doctors on The Body posted to my question. Read it. It's very positive and will hopefully add a bit of peace to some your hearts.

http://www.thebody.com/Forums/AIDS/TreatExp/Archive/Pipeline/Q173719.html Read more »

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