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How Much Does Aptivus Cost

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Aptivus

Brand name: Aptivus Generic name: tipranavir, or TPV Class: Protease inhibitor (PI) Manufacturer: Boehringer Ingelheim, www.aptivus.com , (800) 542-6257 AWP: $1,420.09/month; $419.84 for 95 mL bottle of solution Standard Dose: Two 250 mg capsules with two 100 mg capsules of Norvir, both twice daily. Must be taken with Norvir. Oral solution available; both formulations available for children ages 2 years and older. Must take with...
Ask the Experts

Aptivus

Doc,I've read a lot about Aptivus being good for people who have had resistance to other drugs. Is it ever used for people just starting treatment? As someone who has recently tested positive I'm weighing all my options.Thanks! Rob...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Aptivus is also known as tipranavir and is a recently approved protease inhibitor that has activity against virus that is multi-drug resistant. It is typically used as part of a salvage regimen for patients that have drug-resistant virus. There are... Read more »

What to do - Aptivus?

Doctor, vircotype phenotpype showed mutations at 41L, 43Q, 118I, 210W, 211K and 215S and said I had susecptibility to all NRTI's, "maximal" to retrovir. No nNRTI mutations. PI mutations at 10I, 13V,, 33F, 46I, 48V, 54T, 71V, 74S,...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Hello and thanks for posting. The best answer to your question will depend on some additional information: viral load, CD4 count, previous treatment history, prior resistance tests, and any known antiretroviral medications intolerances. The short... Read more »

RE What to do - Aptivus

Doctor, thank you for your speedy response. To answer your question, I am six years poz. Treatment naive. Last VL's over the past year ranging 250 to now 158. About 8% each time CD4 to CD8. I know I have these NNRTI mutations...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
It is quite unusual, but not unheard of, to have so many resistance mutations in someone who is nave to treatment. But based on the resistance test from your previous <a... Read more »

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain)... Read more »
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