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How Much Do PIs Cost

Here's a taste of what has to offer on this topic:
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Mycobacterium Avium Complex (MAC)

...protect against bacterial infections in the lungs and airways. Rifabutin can reduce the risk of developing MAC by 30-50%. Combinations of these drugs have been tested for MAC prevention, but in all cases increased side effects and cost outweigh any added protection from disease. One worrying outcome of these studies was that some people develop resistant MAC. MAC bacteria were three times as likely to become resistant to clarithromycin taken...
Ask the Experts

Boosted vs. Unboosted Reyataz

There was a study (ARIES) released at IAS 2009 which indicated that unboosted Reyataz performed as well as boosted Reyataz with Epzicom. Has this caused you to change your prescribing practices regarding Reyataz in your clinic? Thanks.
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES early phase induction with ritonavir (without long-term exposure) could yield similar results (with less drug exposure and costs).A couple of points deserve comment. First, this study does not evaluate starting with Epzicom with unboosted... Read more »


Could you possibly give a comparison of the best PIs and how does one choose the best for me
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
...important for you to decide what is most significant for you when choosing meds. Is it pill size, pill number, frequency of dosing, cost? Side effects are important to everyone but which ones are most worrisome to you or less likely to be... Read more »

Kaletra v Reyataz + RVR

If you have private coverage, I thought all PIs were generally tiered the same and thus have tier 2 copays (1 would be generic and 3 would be not covered or % copay). Is it common for an insurer to punish the patient for their doctor perscribing...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...GlaxoSmithKline, the makers of fosamprenavir have sought to level the copayment field, so to speak, by offering to cover the costs of the second copayment- a strategy that has saved many of my patients hundreds of US dollars in copays.Hope this... Read more »

Are 2 PI's Enough?

I am on salvage treatment. I am resistant to NNRTIs and NRTIs. My viral load is 0 and CD4s 300. I did T20 for 18 months and had to discontinue due to ISRs. I take Saquinivir500 and Lexiva with Norvir. I also take 3TC (even though I am resistant...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...potent enough and may be left alone. Adding another agent when the viral load is undetectable is not advisable. It simply adds cost, toxicity, and this strategy has not been proven to change the long-term outcome.In terms of safety, dual PI... Read more »
Test Positive Aware Network


...for 200 mg a day of Norvir (contained in Kaletra) and the higher rate of gastrointestinal side effects compared with boosted PIs using 100 mg Norvir make Kaletra an alternative for treatment-naive people. Four tablets once daily can increase side... Read more »
Test Positive Aware Network


...dosing adjustment required with Subutex or Suboxone, but monitoring is recommended. Tips: Prezista is one of two recommended PIs for initial therapy in treatment-na├»ve people in the U.S. DHHS HIV guidelines. Tibotec received community kudos... Read more »
Test Positive Aware Network


...approved dose (a lead-in dosing, then six 100 mg tablets twice daily). Norvir is primarily used as a boosting agent for other PIs, at smaller doses of 100 to 400 mg, either once or twice a day. See drug label of the other PI. Take missed dose as... Read more »
Test Positive Aware Network


...PI in the choice of preferred options. However, current guidelines usually do not include saquinavir on the preferred list of PIs to start on, as there are other choices in the PI class that have enough advantages over saquinavir. This drug has... Read more »
Connect With Others

PI Monotherapy advice

Posted by logopolis, 2 Replies
Admin OptionsEdit Discussion Close Discussion Edit Your Tags Cancel Delete Discussion Hi, My partner has been asked to take part in a clinical trial - Protease Inhibitor monotherapy versus Triple Therapy. Just gathering some info before he... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law seem not to... Read more »

New to all this... from England

Posted by Jeeves01, 7 Replies
...combination therapy? Also, I have been offered the following choices of combo's, and I wondered if any of you could offer your opinions as to their tolerability, potency etc: - Epzicom + Sustiva - Truvada + Sustiva - Truvada + Reyataz + Norvir ... Read more »

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies
...on Friday approved the use of a new HIV drug, made by Johnson & Johnson <JNJ.N>, in combination with related therapies to help treat patients who do not first improve with other treatment. The drug, Prezista, is a protease inhibitor... Read more »