How Long Does Mitochondrial Toxicity Last

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...

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mitochondrial toxicity and fatigue

Would a one week on "Meds" one week off "meds" be sufficient to slow reverse or halt this disintegration of the Mitochondria ? Regardless of the "it's BAD to stop meds because you will develope a resistant strain !!...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

OK, OK, OK, I get it! You don't want me to say it's BAD to stop meds, because you will develop a resistant strain!!! However, you want me to comment on one-week-on and one-week-off H"IV meds and advise you if this theoretically might... Read more »

MITOCHONDRIAL TOXICITY

Anti-HIV drug side effects linked to mitochondrial toxicity have been around for years. It is obvious with the growing incidence and possible role of lipodystrophy. It's a fact that all nukes inhibit cellular DNA polymerase beta and gamma, thus...

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital

This rather a long question so I hope I can respond to all of it.The risk factors for lipoatrophy inlcude disease characteristics (AIDS, low CD4), genetic characteristics (genes which promote the pro-inflammatory cytokine TNF) and both nucs and PIs.... Read more »

Mitochondrial toxicity

Hi Dr. henry... thanks for your helpful answers. I was under the impression that sustiva/truvada was a very well regarded option for first line treatment, but you mentioned mitochondrial toxicity as a possible side effect. How common is this and...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The rate at which components of the lipodystrophy syndrome develop on some of the newer NRTI combinations (FTC/tenofovir and 3TC/abacavir) seems to be slower that with AZT or D4T combinations (usually with 3TC). Long-term data and independent... Read more »

What can I do to prevent mitochondrial toxicity?

Nelson: I am taking Zerit+Kaletra+Epivir and am very aafraid of this thing I keep hearing about called mitochondrial toxicity. What are the symptoms and what supplements or things can I take to prevent it? I want to get off Zerit but my doctor does...

Response from Nelson Vergel, B.S.Ch.E., M.B.A.

Program for Wellness Restoration

I wish there was a clear answer to your question. As you probably remember from your biology class in school, the mitocondria are tiny cells within a cell that produce energy as ATP from sugars and fats. It seems that nucleoside analogs (NRTIs) not... Read more »

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Toxicity: Your Experiences

Posted by Anonymous

Ok.

I recently tested positive and even though my viral load under 2,000 i have a 389 CD4.

I have been investigating epivir/ziagen and viread..they might be available in a new study on a once daily dosing schedule.

My question is, what do u think about... Read more »

Is gay culture toxic?

Posted by Anonymous, 3 Replies

Everywhere you turn you see images of young, clean shaven, hairless, "buffed" boys gracing the gay mags and movies. Who actually looks like most of these people? All we are given to watch on tv is Will and Grace. They represent like 5% of the entire... Read more »

A Toxic Combination

Posted by Choosing2Liv, 9 Replies

If my dilemma was:

- just dealing with the virus; or

- just suffering with the guilt of cheating on my wife; or

- just the feelings of rejections by those who said they loved me; or

- just the constant blaming, belittlement and bursts of rage from my... Read more »

Are you a long term Sustiva/Truvada user

Posted by soimnotalone, 2 Replies

I am curious about the long term effects of these medicines from actual users. I read the pamphlets and what doctors "claim" but I wanted some feedback from actual users
Thanks for responding ;) Read more »

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