How Long Does Indinavir Take To Work

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Get the Facts

Indinavir (Crixivan)

What Is Indinavir? Indinavir is a drug used as part of antiretroviral therapy (ART). It is also called Crixivan. It is manufactured by Merck & Co. Indinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissor. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these scissors. Who Should Take It? Indinavir...

Ask the Experts

Delavirdine interactions with Indinavir and other antiretrovirals.

Hi Dr. Cohen!Bob Frascino spoke to a group of us in Monterey, CA last week and began for the first time to explain why I have remained undetectable for so long(4+ years) on the same five drug regimen even though my dosing schedule was not precise....

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

Yup. Very clear. Hope the answer is equally lucid.Yes -- delavirdine (for simplicity I'll abbreviate it DLV) does have similar effects on the p450 system as does ritonavir. Not as potent but similar. So yes you can dose reduce the IDV to... Read more »

interaction indinavir-buflomedil

Hi.My name is Edgardo Bottaro, I work with HIV-infected patients (I am a physician) and one of them said me that another doctor prebscribed him buflomedil. She receives indinavir since 4 years ago.I think that buflomedil is an unuseful drug, but I...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Buflomedil is not available to my knowledge in the US. It is a adrenergic agonists with some calcium channel blocker activity that is used for intermittent claudication and other indications. I don't know how it is metabolized since I could... Read more »

INDINAVIR, NORVIR, LAMIVUDINA

Drs.Iam from Bolivia My brother was diagnosed aids 6 months ago he had only 2 cd4 cells The Dr. is givving him Inidavir, Norvir and lamivudina, do you think this is a good combination or do you think he should try different drugs. What is the...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

I suspect your brother is on one more additional drug (probably zidovudine or stavudine) along with his indinavir, ritonavir and lamivudine. If he is not, he should be.This is an older combination of drugs not used much in the US but it should work... Read more »

indinavir intensification

Hi, my partner is on crix/combivir, his first combination, and he has been undetectable (<50) for over 3 years now. However, he ignores the food restrictions and often takes his midday crix late. I've suggested that he try crix/ritonavir...

Response from Rick Stryker, M.D., M.P.H.

University of California Los Angeles School of Medicine

Nope -- I think you are probably right on the money. Your partner is risking it all by taking Crix with food and/or skipping doses. Why go through the hassle of taking meds, and possible side effects, if you don't do everything possible to... Read more »

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