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How Long Does Trizivir Take To Work

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Get the Facts
AIDS InfoNet

Trizivir (Zidovudine + Lamivudine + Abacavir)

What Is Trizivir? Trizivir is a pill that contains three antiretroviral drugs (ARVs) used to fight HIV: zidovudine (Retrovir, AZT), lamivudine (Epivir, 3TC) and abacavir (Ziagen). Trizivir is manufactured by ViiV Healthcare. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 925 ). The drugs in Trizivir are called nucleoside analog reverse transcriptase inhibitors, or nukes. These drugs block the reverse transcriptase...
Ask the Experts

Topping up trizivir

Dr Cohen:I've been on trizivir for about 15 months now, with mixed results. For the first few months it worked fine: v/l was <50 (it was 100,000 when I started after a 15 month break), T-4 climbed from 200 to 460. But after about 6 months...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
So, Mark, you've raised a coupla options. First one now that you are off meds when to restart? And then of course, with what do you restart?Let's take the first one. Short answer as long as the CD4 count is above 200 our current... Read more »


Hello Dr! long time since I last posted! :) Follow up on "starting trizivir" 6/4/2002,8/23/2002,9/25/2002.Treatment naive,29 y.o.(at the time of starting treatment) Been poz since dec 98.As of beginning of treatment (june)VL= 57000 CD4...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for the update-- it's great to hear that you're doing well and the side effects have improved.Trizivir once-a-day is probably not going to make it as a recommended regimen; the metabolism of AZT won't support this kind of... Read more »


Hi doctor Young, thank you for answering my last question. As you suggested for me to take another test I did, my test results were almost the same. Here is the story, my first blood work was kind of bad, T-cells were 251 and viral load was 11,700...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for the follow up.You raise a couple of very important issues.The first is that the risk of lipodystrophy actually appears to go up if one waits longer to start therapy, this would argue against delaying too long to initiate therapy, with... Read more »

Trizivir at the get-go

Hello, My doctor and I took a gamble on Trizivir as a first line therapy. I started with 450k viral load and 290 CD4 cells. We knew data suggested that Trizivir may not work with treatment-naive patients with VL >100k, but the ease of treatment...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
There will certainly be people like you who have had success with this regimen. You do not need to expect failure at this point given your success. We don't have a lot of long term data to know yet how long people can expect to remain on... Read more »
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How long does it take for meds to work?

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After one month on HAAART my loved ones counts are, in comparison to 100000 viral load and cd of under 20, the viral load is now 325 and cd4 is 35. I've heard it takes 3-6 months to get the viral load undetectable and longer to get the cd4 back over... Read more »


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