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How Long Does Stavudine Take To Work

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AIDS InfoNet

Stavudine (Zerit)

What Is Stavudine? Stavudine (Zerit) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. The original patent on stavudine has expired. The U.S. Food and Drug Administration (FDA) approved generic forms of stavudine for sale in the U.S. and under PEPFAR (see Fact Sheet 475 ). Stavudine is also known as d4T or didehydro-deoxythymidine. Stavudine is the most commonly used anti-HIV medication...
Ask the Experts

Concerns about long time Stavudine use in a child

My son was diagnosed with AIDS in 1/20/04. As of 6/2004, he has been on a regimen of Stavudine, Lamuvidine and Kaletra. I am concerned about the long term effects of Stavudine. Are there better combinations? Are we going to be sorry that he stays...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
In adults there has been a unmistakable shift away from using stavudine (Zerit) towards tenofovir (Viread). One of the main reasons for this change is that Viread has a better side effect profile and can be given once daily. The changes in... Read more »

switch back to stavudine?

can a patient who was switched from a stavudine-based regimen to a tenofovir-based regimen go back to the stavudine-based regimen, e.g., if the tenofovir-based drug is no longer available...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Generally in the setting of suppressed virus/good clinical response, tenofovir can be switched to stavudine when facing a shortage of tenofovir with a mild increase in risk for treatment failure and higher risk for side effects long term. Short... Read more »

Stavudine toxicity

what can used in conjuction with lamivudine, stocrin in place of stavudine?What do we need to do to prevent pre-mature aging of body cells?...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
If available and depending on the nature of the problems with stavudine, it is most often switched to tenofovir or abacavir (if HLA B5701 negative or low risk for hypersensitivity reactio) or ziduvudine. Avoiding premature aging in the setting of... Read more »

Stavudine side effect..

I will like to thank you in advance for giving us your advice. I started my med 2010 with the cd4 count of 226 using the combination of tenofovir, lamivadine and efavirenz and after 6month i went for cd4 test came back as 592 which i thought the...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Tenofovir has fewer serious long term side effects than stavudine so if possible it is usually recommended to use tenofovir rather than stavudine. Many patients tolerate stavudine well but the concern is over the long term for risk for fat/metabolic... Read more »
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How long does it take for meds to work?

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