How Long Does Darunavir Take To Work

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Darunavir (Prezista)

What Is Darunavir? Darunavir is a drug used as part of antiretroviral therapy (ART). It is also called Prezista TM and used to be called TMC114. It is manufactured by Tibotec Pharmaceuticals. Darunavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissors. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these...

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Darunavir or not to Darunavir + Low WBC

Hi Joe,I have another question for you. I have recently seen my consultant, and he has suggested changing PI's from Atazanavir to Darunavir. He quotes a few studies that suggest additional benefit for DRV. At the moment I'm undetectable on...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

Michael,Thanks for your questions. Darunavir is now approved for both first line treatment as well as for treatment experienced patients. It is a very potent protease inhibitor, but potency does not seem to be an issue with your regimen since you... Read more »

Prezista/Darunavir

What is the side effects of Prezista/Darunavir?Any lipoatrophy or lipodystrophy?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Good question. The best studies to evaluate lipodysrophy issues is when used in treatment naive patients comparing one regimen to one of the standard of care regimens. Increasingly, the back bone nuke regiments are abacavir or tenfovir + either 3TC... Read more »

Darunavir Cross Resistance

35yo male, healthy, HIV positive (VL stable over the last years @ 25k, CD4 has always been between 720 and 780). My long-term partner is negative, and I finally decided to start treatment to decrease transmission risk. Phenotype and genotype test...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

A darunavir-based regimen with ritonavir boosting is among the preferred regimens in the current DHHS Guidelines for the Use of Antiretroviral Therapy, so the experts agree with you that this is a good option. Darunavir was added to the... Read more »

How long do newer regimes work?

Hello,first many thanks for your work, this site and especially the questions and answers helped me much since diagnosis. I just wanted to ask how long newer regim work on average for treatment naive patients? Thanks ...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Well, that depends on the patient. For someone that has perfect adherence and no medication related side effects, they will work indefinitely. For someone with very poor adherence they don't work very well at all. For someone with mediocre... Read more »

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