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How Long Do Protease Inhibitors Take To Work

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
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Protease Inhibitors - Do They Work?

My lover has been HIV possitive for the last six years. On his last Doctor's appointment his T-Cell Count was way down. He is the healthiest he has ever been, feels great, but has been under some stress as of the last few months. Could this...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
The reason for the optimism surrounding protease inhibitors is that they work very well, and the more we learn about them, the more enthusiastic we become. Data from the Vancouver conference clearly show that the protease inhibitors notonly produce... Read more »

protease inhibitors

Dear Mr. Sowadsky; Please describe Protease Inhibitors, how they work, and their role in drug cocktail therapy....
Rick Sowadsky, M.P.H.

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program
Hi.Thank you for your question.Your question addresses so many issues that it's too long to answer in thisforum. However, a good written source for your questions is in a bookletentitled, "Protease Inhibitors: A New Family of Drugs for... Read more »

Going off Protease Inhibitors

I am in a situation, like many, where the protease inhibitors are not really working for me very well any more. My T cells are at 300 and my viral load is at 29,000. I am a long term survivor (ten years) who was diagnosed with AIDS as a result of...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your question.It certainly sounds like you have evidence of viral resistance to your current treatments. An important decision at this point is whether to continue on therapy (with a treatment switch) or to discontinue therapy.I probably... Read more »

Minor resistance to Protease Inhibitors (more details)

I wrote to you yesterday regarding my resistance report although I am not on meds. The report was as follows. Potential low level resistance to IDV Protease Inhibitors, all others are susceptible (ie: APV, ATV, LPV, NFV, RTV and SQV) Nucleoside RTI...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Nick-Thank you for your post, comments and follow up.I don't think that your resistance pattern should prove too significant in the long-term. You have plenty of very reasonable first-line PI options that should work very well.Good luck... Read more »
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Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

10 years and protease are finally working...

Posted by Anonymous
10 years and protease are finally working for me. It only took
going through all four. Mode of transmission: unknown.
Ex-hustler, dope fiend, alcoholic, sadomasochist,recovering
southern baptist, living in Los Angeles but use to travel
extensively,... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »