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How Long Do Protease Inhibitors Stay In Your Body

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Body Shape Changes (Lipodystrophy)

...causes lipo. There are different causes for fat loss and fat gain. Fat Loss Zidovudine (Retrovir, AZT) and stavudine (Zerit, d4T) are linked to fat loss. Efavirenz (Sustiva) may also contribute. Fat Gain One theory is that protease inhibitors interfere with the body's processing of fat. However, some patients who have never taken protease inhibitors have lipo. Another theory is that insulin resistance plays a role in lipo. People with...
Ask the Experts

Why only Norvir for boosting?

I am curious as to why Norvir is the only drug used for "boosting"? Many people simply cannot tolerate Norvir and others refuse to take it because of Abbott's price gouging of the drug. Are there any other older P.I.'s being studied for their...
Edwin DeJesus, M.D., F.A.C.P.

Response from Edwin DeJesus, M.D., F.A.C.P.

...something that has been haunting the HIV research community at all levels for over a decade. Ritonavir works for boosting other protease inhibitors because it is a very strong inhibitor of some enzymes in the cytochrome P540, a complex enzyme... Read more »

Am I taking too many meds?

Dear Dr. McGowan,About 2 months ago I was given a new cocktail by my physician. When I started this combination my VL was undetectable and my CD-4 cells were 310. The virus is resistent to most of the older type meds but now I am on: TMC125,...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
...who have been on several different combinations will have virus that is partly resistant to nucleoside analog inhibitors and protease inhibitors. It is usually best to use fully active or new drugs but sometimes if there aren't 3 fully active... Read more »

Protease Inhibitors and Living with HIV/AIDS

Just wondering, is there a train of thought that protease inhibitors may ultimately prevent the possibility of AIDS occuring and basically have people living with HIV for an entire lifetime? Upon initially beginning treatment for hiv is it possible...
Rick Sowadsky, M.P.H.

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program
...Thank you for your questions.When it comes to the protease inhibitors and other antiviral therapies, there is good news and bad news.The good news:1) Treatments have been shown to significantly Read more »

protease inhibitors

Dear Mr. Sowadsky; Please describe Protease Inhibitors, how they work, and their role in drug cocktail therapy.
Rick Sowadsky, M.P.H.

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program
...issues that it's too long to answer in thisforum. However, a good written source for your questions is in a bookletentitled, "Protease Inhibitors: A New Family of Drugs for the Treatment ofHIV Infection. What they are, how they work, when to... Read more »
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are Read more »
Gay Men's Health Crisis

Debate Widens Over Protease Inhibitor Side Effects

...protease inhibitor-treated patients. At the 5th Retrovirus Conference last winter, Dr. Cooper reported that 64% of his patients on protease inhibitors showed signs of lipodystrophy (abstract 410). At a late breaker in Geneva, his colleague Andrew... Read more »
AIDS InfoNet

Atazanavir (Reyataz)

...What Is Atazanavir? Atazanavir, also called Reyataz, is a drug used as part of antiretroviral therapy (ART). Atazanavir is a protease inhibitor manufactured by Bristol-Myers Squibb. Atazanavir was approved by the FDA in 2003. Generic versions... Read more »
The Body PRO

What Have We Learned About Lipodystrophy, High Cholesterol, Diabetes, and Long-Term Complications of Protease Inhibitors? Or, What About Protease Paunch?

...HIV(+) women after initiation of protease inhibitor therapy Poster Session 12319: Lipid abnormalities associated with use of protease inhibitors: Prevalence, clinical sequalae and treatment Session 336/32173: Alterations in body fat... Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
...where this will lead, but she is going to go stay with her mother who will "nag" her to take her meds. This does not seem lke a long term solution unless she intends to stay with her mother. The doctors strongly advised her to stay in the... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A. This is a question for the gentlemen with Read more »

positive since March 3 1985...

Posted by Anonymous, 2 Replies medical background at the present I seem to be doing pretty good. I am faced with the question if I should go on the Protease Inhibitors. My t-4 cells have droped to 200, and the Viral Load is up to 330,000. The doctor aid he would ... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »