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How Long Do PIs Take To Work

Here's a taste of what has to offer on this topic:
Get the Facts
The Well Project


...Work for You References What Is PK? Pharmacokinetics, also known as PK, is the study of how medications behave in and move through the body. PK is used to figure out how much drug gets into your bloodstream and how long it stays there. Scientists study PK to determine the best dose for an HIV drug. The dose must be high enough to keep HIV from reproducing, but not so high that it causes many side effects. How Is PK Studied? ...
Ask the Experts

coformulated PI's et al.

I take boosted Lexiva and Truvada. From what I read it seems that all PI's should be boosted. So why aren't all PI's or at least the more common ones not coformulated with norvir rather than having to take two pills. Both meds particularly the...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...[Reyataz])- much to the disadvantage of patients.FWIW, we have had excellent responses and tolerability of other once-daily PIs, like Lexiva and Reyataz.BY Read more »

Re: PI monotherapy

I was intrigued by your reponse to the question about PI monotherapy. Based on what Ive read here and in other forums I expected a resounding NO to this idea, but your response was quite the opposite. I have been infected since early 2005, not on...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...Hello, and thanks for posting. Kaletra monotherapy is an acceptable treatment option in my book. It works as well as many triple drug combinations which are included in the guidelines. It does not work every time, but when it does Read more »


Out of the available and tested p.i.'s which seen to have the least side effects,and which the most?I read that viracept is "the baby asprin p.i" in terms of side effects, and if you don't experience the diarreaha you'll be in good shape.Does this...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...To properly answer your good questions would take a very long time. The optimal PI for a given patients depends on a number of factors (individualized) including prior treatment history, Read more »

Is there anything significant in the works?

Hi, great job on the forum guys I've learned a lot. I have recently been infected and am wondering if there are any promissing drugs in the works right now that will be available in the next 4-5 years. I would like to delay treatment as long as...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...the pipeline for the treatment of HIV. Some of these are improvements on existing classes of medications (second-generation PIs, NNRTIs), others represent drugs for novel targets (like therapeutic vaccines, integrase inhibitors, fusion... Read more »

An Overview of Norvir (Ritonavir)

...mineral-fortified foods. Ritonavir capsules should be stored in the refrigerator; however, they can be kept at room temperature as long as they are used within 30 days. Ritonavir tablets should not be exposed to high humidity levels outside the... Read more »
The Well Project

Starting HIV Treatment

...reasons that people don't stick to their HIV regimen. Beprepared! Ask your health care provider about the possible short- and long-termside effects of your particular regimen. There are medicines that can be used to treat short-term side effects... Read more »
The Well Project

Drug Interactions and HIV/AIDS

...Norvir (ritonavir) is a protease inhibitor (PI) that makes the liverenzymes work slower. This keeps some other drugs in the body longer and athigher levels. So if Norvir is given with another PI, like Crixivan (indinavir), it "boosts" Crixivan.... Read more »
Test Positive Aware Network

Selzentry the types of HIV that a person can have: CCR5-tropic (R5) virus and CXCR4-tropic (X4) virus. (Tropism is pronounced with a long "o," as in "okay.") HIV latches on to the CD4 receptor on the surface of some human T-cells (hence, CD4+ T-cells),... Read more »
Connect With Others

PI Monotherapy advice

Posted by logopolis, 2 Replies
...months will 100% adherence and an undetectable viral load, however as we all know this is a powerful and toxic med so in th elong term the Doc thinks monotherapy is better. Just wanted to put this out and see if anyone else has trialled or is... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A. This is a question for the gentlemen with Read more »

P.I. versus NNRTI

Posted by Anonymous, 2 Replies
Hi. I am hearing a lot of good things about the Truvada + Reyataz + Norvir combo. I am just about to commence my first line regimen, and wanted to enquire as to what anybody else thought of this combo? I am starting therapy with a relatively high... Read more »

off of disability and off to work

Posted by Anonymous, 3 Replies pos for 10 years......almost dead 2 years back to work full time and coming off of disability......anyone else in the same boat....would like to hear from you...... marc Read more »