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How Integrase Inhibitors Work

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AIDS InfoNet

Other Antiretroviral Drugs in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Integrase Inhibitors After HIV's genetic code is changed from a single strand to a double strand by the reverse transcriptase enzyme, it gets inserted (integrated) into the genetic code of the infected cell. Then the HIV genetic code gets "read," producing new viruses. Scientists hope that integration will be another point in the HIV life...
Ask the Experts

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

Merck integrase inhibitor

Dear Doctor,You wrote a couple of days ago that the Merck integrase inhibitor will be available shortly. As a treatment experienced hiver (+ since 1990) I would like to know what this med will offer in comparison to the already available...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
This will be a medication that works completely differently than any of the currently available HIV meds. Therefore, for someone like yourself who has had HIV for a while and may have virus that has accumulated HIV drug resistance, the integrase... Read more »

Integrase inhibitor

Hello doctor,Any possibility dolutegravir could to be used as Monotherapy even though there's not available data yet?...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hi and thanks for posting.While the investigational integrase inhibitor dolutegravir has many positive attributes, there's no reason to think that this medication will work as monotherapy. Integrase inhibitors, generally speaking are similar... Read more »

New Integrase inhibitor and lipodystrophy risk

There is a once a day integrase inhibitor with a non-PI booster coming up soon, isn't there? What is the integrase inhibitor called and what class does the booster belong to? Setting aside the relative newness of these drugs (and therefore the...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Hello and thanks for posting. The new integrase inhibitor medication is called elvitegravir and the booster is GS 9350. The booster is one of a new class of drugs designed specifically to inhibit the CYP3A liver enzyme system. We already know that... Read more »
Connect With Others

Integrase Inhibitor

Posted by Survivor
I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Today's LA Times Article - Integrase Inhibitors

Posted by Anonymous
Very hopeful! (Despite the sad title.)

http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply
Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »