Advertisement

The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol

How Fusion Inhibitors Work

Here's a taste of what TheBody.com has to offer on this topic:
Get the Facts
AIDS InfoNet

Fusion and Attachment Inhibitors

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 430 : non-nucleoside analog reverse transcriptase inhibitors (NNRTIs or non-nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 470 : other antiretroviral drugs in development Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug...
Ask the Experts

Fusion Inhibitors

Can you tell me what a fusion inhibitor exactly is and decribe how it works in the body?...
Don Kurtyka, ARNP

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine
Fusion inhibitors are a subclass of drugs called entry inhibitors. Unlike previous HIV medications that target HIV once it attacks and infects a T-cell, entry inhibitors prevent HIV from being able to attach to a T-cell. By keeping HIV from... Read more »

mechanism of action of fusion inhibitors

how do fusion inhibitor act to treat HIV...
Don Kurtyka, ARNP

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine
There's a ton of information on thebody.com that describes how fusion inhibitors work. You might want to also check out www.fuzeon.com.If you're more into graphics, check out the video link in this message!... Read more »

Fusion inhibitors

I would very much like to know if fusion inhibitors are going to produce loss or fat acumulations like protease inh., and if the new Tenofovir has more of these kind of side effects than other transcriptase inhibitors. Thank you...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
T-20 (the only fusion inhibitor in wide use) has not been associated with lipodystrophy yet. Since it works extracellularly there is hope that some of those problems associated with unwanted activity of a drug inside cells might be avoided. It... Read more »

Fusion inhibitors and clinical trials.

I have recently reached the point where I need to start taking anti-HIV medications and I am seeking your advice on how to proceed.Our local AIDS Clinical Trials Unit needs people who are treatment-naive for a study involving fusion inhibitors in...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
I think that your primary ID doctor is correct. A simple regimen would probably work as well with fewer side effects. Fusion inhibitors require daily injections and are no walk in the park. If you do decide to participate in this trial you should... Read more »
Connect With Others

Fusion Inhibitor News?

Posted by Anonymous
Does anyone know if the fusion inhibitor trials (phase III) are going OK, or where to go for an update? Last I heard 700 patients in 100 countries were in the study for T-20(?)
I went to the Trimeris site and didn't see anything new.

Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply
Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »