How Does Zidovudine Work

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Get the Facts

Zidovudine (Retrovir, AZT)

What Is Zidovudine? Zidovudine (Retrovir) is a drug used for antiretroviral therapy (ART). It was first manufactured by GlaxoSmithKline. It is manufactured by ViiV Healthcare. The patent on zidovudine expired in 2005 and several generic versions have been approved. Several are available under PEPFAR (see Fact Sheet 475 ). Zidovudine is also known as azidodeoxythymidine, AZT or ZDV. Zidovudine was the first drug approved for the treatment of...

Ask the Experts

ZIDOVUDINE

I am working in treatment advocacy with HIV patients. Recently one of my patients stated that she was told by a kidney specialist that 300 mg of Zidovudine is to strong for her liver. she is having difficulty having the recommended dose of 100 mg...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

It is somewhat unusual for standard doses of zidovudine to be too strong for the liver . If she is seeing a kidney specialist and has some degree of kidney failure then the dose of lamivudine may be too high for her kidneys and the dose may need to... Read more »

Switch from Zidovudine

My wife with a baseline CD4 of 83 (12.8%), and viral load of 2071 is on Zidovudine, Lamivudine, and Nevirapine for 6 weeks. She is also taking Bactrim DS for 2 weeks. While she has tolerated the drugs, she has recently reported a decline in white...

Response from Brian Conway, M.D.

University of British Columbia

You ask a very analytical question. Your doctor is right in that the combination of Bactrim and zidovudine may be particularly bad for the white blood cells, especially in someone who is deficient in folate. Sometimes, before making any changes in... Read more »

zidovudine, didanosine, kaletra

Is the above combination suitable for one considered to be resistant to combivir and effavirenz? I have come across these in the internet. My doctor thinks I could be resistant to combivir and effavirenz. I have been on them for 2 years. Due to...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Ideally speaking, if resistance develops to a HAART (highly active antiretroviral therapy) regimen, I recommend getting a resistance test to help guide the choice of the next regimen. If resistance testing is not an option in Zimbabwe and your... Read more »

Is it safe to take creatine with Lamivudine + Zidovudine and efavirenz?

Hello Mr. Vergel, Im marc from Beirut 29 years old just diagnosed with HIV from 3 month ago and had to start the treatment directly, I am now on Duovir (Lamivudine + Zidovudine) and Effavir (efavirenz).Honestly I used not to skip the gym used to go...

Response from Nelson Vergel, B.S.Ch.E., M.B.A.

Program for Wellness Restoration

I am glad you are regaining control of your health after adjusting from the shock of your HIV diagnosis. As you know, we can live long and healthy lives, and many of us become even more motivated to exercise, eat well and take care of ourselves... Read more »

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