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How Does The Drug Azt Work

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Get the Facts
AIDS InfoNet

Zidovudine (Retrovir, AZT)

...manufactured by ViiV Healthcare. The patent on zidovudine expired in 2005 and several generic versions have been approved. Several are available under PEPFAR (see Fact Sheet 475 ). Zidovudine is also known as azidodeoxythymidine, AZT or ZDV. Zidovudine was the first drug approved for the treatment of HIV. It is a nucleoside analog reverse transcriptase inhibitor, or nuke. These drugs block the reverse transcriptase enzyme. This enzyme...
Ask the Experts

How Quickly do drugs work?

My friend in Mexico was diagnosed quite late--after a bout with p.pneunomia and karposi's sarcoma. He is somewhat weak and not fully recoverd from the pneumonia. The Karposi's is small, but getting worse. He just started taking Kaletra and...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...hear that your Mexican friend has found his way to antiretroviral therapy. The combos of lopinavir/ritonavir (Kaletra) and AZT/3TC (Combivir) should be very potent and if adhered to, should drive his viral load to undetectable levels within a... Read more »

AZT anemia

I started on Combivir and Sustiva for my first treatment about three months ago. After two months, my viral load had dropped to undetectable and my cd4 count had risen nearly 20%! (Boy was I happy)But, my doctor suspected AZT-induced anemia...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
...case I would say the risk of you having developed drug resistance is very low. Given Sustiva stays in the system longer than AZT and 3TC (the drugs in Combivir) some hedge their bets and keep taking their Combivir for a few days after stopping... Read more »

AZT TONGUE PIGMENTATION- AZT 2 ever?

Hi Doctor Young, Does AZT cause a nasty looking pigmenation (black to purple spots to develop on the inside of the tongue and mouth?) Does the AZT that is offered as medicine today in combination with other drugs still produce this result? AZT...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...Zidovudine (ADV, AZT) can cause hyperpigmentation of nails and skin- I suppose that it could cause hyperpigmentation of the tongue, but I am not aware Read more »

Ribavirin and AZT/D4T

Hello Doctor,I heard that Ribavirin cancels out AZT and also D4T. The studies to this topic are all "in vitro". What really happens in case you take a HIV-Combo with AZT or D4T and INF+Riba? In an small study there where no negative effects seen,...
Douglas T. Dieterich, M.D.

Response from Douglas T. Dieterich, M.D.

New York University, School of Medicine
...There have several small lab studies suggesting that ribavirin might compete for phosphorylation with AZT and D4T. At our site, at Johns Hopkins, in France and Spain, we now have data on over 100 people treated with ribavirin and despite Read more »
Articles
The Well Project

HIV Drug Resistance

...classes of HIV drugs: Nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs) such asRetrovir (zidovudine or AZT) and Ziagen (abacavir) Non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as Sustiva(efavirenz) and... Read more »
AIDS InfoNet

Lamivudine (Epivir)

...according to instructions, on schedule, and not to skip or reduce doses. Lamivudine seems to be able to reduce resistance to AZT. After people develop resistance to AZT and then take lamivudine, AZT seems to work better for them. How Is... Read more »
Project Inform

Blood Work: A Complete Guide for Monitoring HIV

...be due to an iron deficiency or chronic disease. MCV is generally higher than normal in people taking Retrovir (zidovudine, AZT) or in people with vitamin B12 and folic acid deficiencies. Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular... Read more »
The Well Project

Drug Interactions and HIV/AIDS

...and Vidextogether. Some drugs work against each other and should not betaken together. An example is Retrovir (zidovudine, AZT) and Zerit. Drugs and Other Substances That May Interact With HIV Medications There is a long list of... Read more »
Connect With Others

Get The Facts

Posted by Anonymous, 2 Replies
...confidential testing, the results are kept in a medical file. TREATMENT: There is no cure for HIV/AIDS. However several drugs such as AZT work to slow the progression of HIV infection. People who are HIV positive often help strengthen their... Read more »

Combivir & Kaletra

Posted by movingon
...is currenlty trying the regimen of Combivir & Kaletra - how does it work for you ? I know combivir contains the dreaded AZT, but i have read accounts of people who have been on combivir for 10 years or more, and have ZERO problems on it. ... Read more »

BOYCOTT Project (RED) Auction Sothebys

Posted by Alex1, 2 Replies
...of ART in Africa is leading toward pharmagenocide - direct medical killing. It is has been scientifically demonstrated that AZT and other ART drug regimes are actually causing Iatrogenic-AIDS - medically induced AIDS - or what Prof. Peter... Read more »

about to start treatment

Posted by Anonymous, 4 Replies
...induction/maintenance strategy starting with an intense four-drug Kaletra (LPV/r, lopinavir/ritonavir)-based regimen along with Combivir [AZT/3TC] + Viread [tenofovir]. can you tell me side effects with these? also is facial lipotrophy a side... Read more »