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How Does Lopinavir Inhibit Hiv

Here's a taste of what has to offer on this topic:
Get the Facts

An Overview of Kaletra (Lopinavir/Ritonavir)

... Drug Class: Protease Inhibitors Lopinavir/ritonavir, also known as Kaletra, is a type of medicine called a protease inhibitor (PI). PIs act by blocking protease, a protein that HIV needs to make more copies of itself. HIV/AIDS-Related Uses Lopinavir/ritonavir in capsule and oral solution form was approved by the FDA on September 15, 2000, for use with other antiretrovirals in the treatment of HIV infection in adults and children 6...
Ask the Experts

ecstasy with hiv tablets

Just wondering what happens if you are on Kaletra and combivir, and the last dose you took was 3 hours ago, and then you take an ecstasy pill? Will it have bad effects? Or will it be ok?
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
...Ecstacy is broken down or metabolized in the body by the same pathway as many of the HIV medications. Kaletra is a combination of lopinavir and its booster ritonavir. When ecstacy is taken with ritonavir (Norvir), the amount of ecstacy in your... Read more »


Hi Doc,I am HIV positive and am also taking warfrin for thrombosis. What effect does warfrin have on my ARV. I realize my CD4 has dropped (not imrpoving) since taking warfrin
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...(NNRTIs).DATA SYNTHESIS: The drugs used in the case reports were limited to 6 antiretroviral agents (efavirenz, nevirapine, lopinavir/ritonavir, nelfinavir, saquinavir, ritonavir). The mechanism of interaction between antiretroviral agents and... Read more »

Kaletra and Dilantin

Dear Dr. I recently had a seizure and went to a neurologist. He gave me a script for 1 month of dilantin and then will do further test. Is there any interactions between these medications? Thanks
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There is a potential serious interaction between Dilantin and protease inhibitors including lopinavir (in Kaletra). There is concern about decreased efficacy of both drugs. Close monitoring of Dilantin levels and plasma HIV RNA Read more »

Kaletra and Grapefruit Juice

I just heard that I shouldn't drink Grapefruit Juice since I am taking Kaletra (monotherepy).Now I am freaking out because I've recently have been drinking about 12 ounces or so a day for the last few weeks.Sometimes to swallow my Kaletra.Is this...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...Grapefruit juice can have a variable but generally negative effect on lopinavir levels. I would also be more concerned if you have hsitory of prior drug resistance including to protease inhibitors. Separating Read more »
U.S. Centers for Disease Control and Prevention

Prospective, Randomized, Open-Label Trial of Efavirenz vs. Lopinavir/Ritonavir in HIV+ Treatment-Naive Subjects With CD4+ Less Than 200

... Antiretroviral therapy based on efavirenz (EFV) is more effective than lopinavir/ritonavir (LPV/r)-based therapy among treatment-na├»ve patients with advanced disease, a new study found. The study enrolled Read more »
The Body PRO

Atazanavir Noninferior to Lopinavir in Treatment-Naive HIV-Infected People

...U.S. Food and Drug Administration [FDA] for such use. In a large study presented at CROI 2008, atazanavir was compared with lopinavir/ritonavir, a preferred first-line drug also known as Kaletra. To discuss the results I spoke with Dr. Donnie... Read more »
The Body PRO

908 Plus Lopinavir/Ritonavir Does Not Appear to Be a Viable Regimen for HIV-Infected Patients

...between these two agents were the subject of extensive discussion a couple of years ago (see coverage from The XIV International AIDS Conference 2002 ). In the end, it was concluded that both the lopinavir and amprenavir levels were... Read more »
The Body PRO

Response to Lopinavir/Ritonavir in HIV-Infected Patients Coinfected With Hepatitis C and/or Hepatitis B

...with CD4+ cell counts >250 or men with CD4+ cell counts >400. This systematic review of several industry-sponsored studies of lopinavir/ritonavir (LPV/r, Kaletra) provides some estimate of the relative risk of the hepatotoxicity of this agent.... Read more »
Connect With Others

Am I Infected

Posted by delhiguy, 3 Replies
I am 30 YO guy. Worried that I may have got infected. I met this friend of mine on 5th of Dec 2010 which was just a causual meeting after 5 years. After having drinks she started touching me and I got aroused and we end up mating. While in act, she... Read more »

get ready, get set.............. go meds

Posted by dealin_wit_it, 3 Replies
ok, just got back from the doc's office and he told me that as of today, i'm on meds. we've already talked about this and i already decided to start with combivir and kaletra. he agrees, until my geneo type comes back from the labs. i want to know... Read more »


Posted by Anonymous, 1 Reply
...Exploring: NIAID, NIH, U.S. DHHS March 2005 HIV Infection and AIDS: An Overview INTRODUCTION AIDS (acquired immunodeficiency syndrome) was first reported in the United States in 1981 and has since Read more »


Posted by Survivor, 1 Reply
...What do HIV/AIDS Doc's do, when they are not seeing you? Ben Young, M.D. In Ukraine, Clinicians Read more »