Advertisement

The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol

How Does Hiv-1 Protease Inhibitors Work

Here's a taste of what TheBody.com has to offer on this topic:
Get the Facts
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

How do protease inhibitors work?

I was wondering how a protease inhibitor acts on the protease of HIV. What does this protease enzyme do that it needs to bestopped?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...particle from an infected cell. If the proteins necessary for making new virus particles cannot be modified (cleaved) by the protease inhibitor, then the virus particle that gets released from the cell is defective. It cannot infect new cells,... Read more »

Protease Inhibitors Work for Some Not For Others

Why do some protease inhibitors seem to suppress viral loads to nearly 0in some patients and can not in other patients?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...The most common reasons for protease inhibitor failure in my experienceare: Noncompliance: the drugs are taken erratically, with missed ordelayed doses Lack of effective combination Read more »

Protease Inhibitors - Do They Work?

My lover has been HIV possitive for the last six years. On his last Doctor's appointment his T-Cell Count was way down. He is the healthiest he has ever been, feels great, but has been under some stress as of the last few months. Could this be the...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...The reason for the optimism surrounding protease inhibitors is that they work very well, and the more we learn about them, the more enthusiastic we become. Data from the Vancouver conference Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when Read more »
Articles
University of Michigan

Compound Has Potential for New Class of AIDS Drugs

...that mechanism works from the current drugs used to keep the HIV from maturing and replicating, she says. Current drugs called protease inhibitors work by debilitating the HIV-1 protease. This does the same, but in a different way, Carlson says.... Read more »
The Body PRO

Clinical Trials of HIV-1 Protease Inhibitors

... GW433908, a Novel Prodrug of the HIV Protease Inhibitor (PI) Amprenavir (APV): Safety, Efficacy, and Pharmacokinetics (PK) (APV20001) (Poster 333) Authored by R. Wood, K. Arasteh, Read more »
The Body PRO

Clinical Trials of HIV-1 Protease Inhibitors

...the latest Department of Health and Services Guidelines (released February 5, 2001) endorsed it in as one of the first-line protease inhibitor combination when used with nucleoside analogues. Questions remain as to the optimal dosing of both... Read more »
PWA Coalition Colorado

New HIV Protease Inhibitors

... Introduction Benefits of Early Protease Inhibitors Limitations of Early Protease Inhibitors Challenges to Protease Inhibitors: Non-Nucleoside RT Inhibitors The Rise of Boosted Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
...hospital. His frustration is partly based on the fact that he can not convince her to do anything and short of staying home from work (which they can certainly not afford) he cannot be there to monitor her meds. I don't know where this will lead,... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law seem not to... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...more than adequate - his infusions (intervals and amounts) indicate it's near impossible that this is happening. His product is working. We're having a difficult time convincing our local doc (conservative infectious disease specialist, with... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »