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How Do Protease Inhibitors Work

Here's a taste of what has to offer on this topic:
Ask the Experts

How do protease inhibitors work?

I was wondering how a protease inhibitor acts on the protease of HIV. What does this protease enzyme do that it needs to bestopped?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...particle from an infected cell. If the proteins necessary for making new virus particles cannot be modified (cleaved) by the protease inhibitor, then the virus particle that gets released from the cell is defective. It cannot infect new cells,... Read more »

Protease Inhibitors - Do They Work?

My lover has been HIV possitive for the last six years. On his last Doctor's appointment his... Read more »

Protease Inhibitors Work for Some Not For Others

Why do some protease inhibitors seem to suppress viral loads to nearly 0in some patients and can... Read more »
San Francisco General Hospital

How the Protease Inhibitors Work

...The protease inhibitors represent one of the best examples of the application of basic scientific knowledge to rational drug design. Relatively soon Read more »
Henry J. Kaiser Family Foundation

European Commission Approves Boehringer Ingelheim's Protease Inhibitor Aptivus to Treat Drug-Resistant HIV

... The European Commission has approved Boehringer Ingelheim 's protease inhibitor Aptivus to be used in combination with Abbott Laboratories ' Norvir for HIV/AIDS patients who have become resistant to other Read more »
Henry J. Kaiser Family Foundation

Tibotec Experimental Protease Inhibitor Successfully Lowers Viral Loads of HIV Patients With Drug Resistance, Study Shows

...Retroviruses and Opportunistic Infections in Boston said last week, Wall Street Journal reports ( Wall Street Journal , 2/25). Protease inhibitors work by blocking the action of an enzyme that cuts HIV proteins into the shorter sections that... Read more »
Test Positive Aware Network

The Protease Inhibitor Drugs

...Currently, there are eight approved compounds for the treatment of HIV infections that are in the class known as protease inhibitors. Of all classes of HIV medications, the protease inhibitors are the most complex in terms of pharmacokinetics,... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »

Request for an Interview

Posted by lawrencegoodman
...I am a reporter with POZ Magaizne working on a story about the use of protease inhibitors. I am looking for someone who had a really bad experience on them. Please email me if you'd like to share your experience with Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...more than adequate - his infusions (intervals and amounts) indicate it's near impossible that this is happening. His product is working. We're having a difficult time convincing our local doc (conservative infectious disease specialist, with... Read more »

Am I?

Posted by Anonymous, 1 Reply the book "Inventing the AIDS Virus" by Peter H. Duesberg (Regnery Publishing, INC; Washington DC, 1996): In 1988 I was working as a consultant at Specialty Labs in Santa Monica, CA, setting up analytic routines for the Human... Read more »