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How Do Protease Inhibitors Work To Inhibit The Replication Of Hiv

Here's a taste of what TheBody.com has to offer on this topic:
Get the Facts
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when Read more »

How do protease inhibitors work?

I was wondering how a protease inhibitor acts on the protease of HIV. What does this protease enzyme do that it needs to bestopped?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...particle from an infected cell. If the proteins necessary for making new virus particles cannot be modified (cleaved) by the protease inhibitor, then the virus particle that gets released from the cell is defective. It cannot infect new cells,... Read more »

Protease Inhibitors - Do They Work?

My lover has been HIV possitive for the last six years. On his last Doctor's appointment his T-Cell Count was way down. He is the healthiest he has ever been, feels great, but has been under some stress as of the last few months. Could this be the...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...The reason for the optimism surrounding protease inhibitors is that they work very well, and the more we learn about them, the more enthusiastic we become. Data from the Vancouver conference Read more »

Protease Inhibitors and Living with HIV/AIDS

Just wondering, is there a train of thought that protease inhibitors may ultimately prevent the possibility of AIDS occuring and basically have people living with HIV for an entire lifetime? Upon initially beginning treatment for hiv is it possible...
Rick Sowadsky, M.P.H.

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program
...Thank you for your questions.When it comes to the protease inhibitors and other antiviral therapies, there is good news and bad news.The good news:1) Treatments have been shown to significantly Read more »
Articles
Henry J. Kaiser Family Foundation

Protein Accumulation Might Cause Fat Deposits, Other Side Effects in HIV-Positive People Taking Protease Inhibitors, Study Says

...Similarities between genetic conditions that cause early aging and side effects experienced by some HIV-positive people when taking protease inhibitors might explain the fat accumulation associated with the drugs, according to a study published... Read more »
The Body PRO

Abstract No. 331: Viral Fitness in Patients with Discordant CD4 and Plasma HIV RNA following Protease Inhibitor Failure

...authors begin with the observation that discordant evolution of CD4 counts and plasma viral RNA is observed in patients following protease inhibitor therapy. They offer several hypotheses: The fall in CD4 is only delayed with regard to the... Read more »
Test Positive Aware Network

How HIV Drugs Work 101

...retrovirus, these drugs are also called antiretrovirals.) Nucleosides and non-nucleosides work to stop HIV from infecting cells and protease inhibitors stop infected cells, from reproducing the virus. In addition, new classes of drugs to treat... Read more »
Test Positive Aware Network

How HIV Drugs Work

...inhibitors (NRTIs) nucleotide reverse transcriptase inhibitors (NtRTIs) non-nucleoside reverse transcriptase inhibitors (NNRTIs) protease inhibitors (PIs) fusion inhibitors Fusion inhibitors work outside the CD4 cell by inhibiting HIV from... Read more »
Connect With Others

working with hiv positive person

Posted by work35, 1 Reply
...Hello.. I hope this is not an ignorant question but here goes.. two part question.. Part one.. I just found out my co-worker is hiv positive.. he is healthy thank god.. and i really like him but I admit I am VERY uncomfortable at work.. we both... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...more than adequate - his infusions (intervals and amounts) indicate it's near impossible that this is happening. His product is working. We're having a difficult time convincing our local doc (conservative infectious disease specialist, with... Read more »

Bush ignores HIV prevention methods that work

Posted by bradford, 2 Replies
...U.S. President George Bush ignores HIV prevention methods that work! Who is informing the president on HIV and AIDS? Failure of the American president to recognize the need to promote condoms Read more »