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How Do Protease Inhibitors Affect Hiv

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

protease inhibitors toxicity

I have been reading a lot about protease clinical trials.and there it has been mentioned that inhibitors could be very toxic on a cellular level. my question is, how long after taking inhibitors can the researchers see if there is toxicity on a...
Barbara McGovern, M.D.

Response from Barbara McGovern, M.D.

Tufts University School of Medicine
...concern; however, it also needs to be stated that the vast majority of patients tolerate their medications well. The data on how protease inhibitors may affect tissues on a "cellular level" are really derived from experiments in vitro (in a... Read more »

the affects of protease inhibitors on mental health

what are the pshyicogical affects of hiv and hiv drugs(combivir, viracept)
Michael Shernoff, M.S.W.

Response from Michael Shernoff, M.S.W.

Psychotherapist and Author
Your question is too vague for me to understand what it is specifically you are asking. Please be much more specific if you resubmit your question.Michael Shernoff, MSW Read more »


Hello from Sweden, I am 66 years, master swimmer got HIV from Asia 3 years ago Now first week on Stockrin and Kivexa, feels good. How dos it affect my sport as a swimmer, I feel tierd and not in good shape, and I have doubbled my exercise Can i do...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...can we skip the nucleosides altogether? There are nuke sparing regimens available and an example would be a combination of a protease inhibitor and Stocrin (Sustiva, efavirenz). Another way to control HIV replication without nucleosides is to... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when Read more »
U.S. Food and Drug Administration

New Label Information Affecting All Approved Protease Inhibitors for Treatment of HIV

... The approved protease inhibitors for the treatment of HIV-1 infection now all include the following drug-drug interaction information: Revatio (sildenafil) Read more »
U.S. Centers for Disease Control and Prevention

Quality of Life, Emotional Status, and Adherence of HIV-1-Infected Patients Treated With Efavirenz Versus Protease Inhibitor-Containing Regimens

...retrotranscriptase inhibitors plus efavirenz (Group One; 51 patients) or two nucleoside retrotranscriptase inhibitors plus one or more new protease inhibitors (Group Two; 49 patients). QOL was assessed by a five-point item adapted from the HIV... Read more »
Henry J. Kaiser Family Foundation

Protein Accumulation Might Cause Fat Deposits, Other Side Effects in HIV-Positive People Taking Protease Inhibitors, Study Says

...Similarities between genetic conditions that cause early aging and side effects experienced by some HIV-positive people when taking protease inhibitors might explain the fat accumulation associated with the drugs, according to a study published... Read more »
The Body PRO

Abstract No. 331: Viral Fitness in Patients with Discordant CD4 and Plasma HIV RNA following Protease Inhibitor Failure

...viremia and decrease in CD4 count. A loss of viral fitness significantly correlates with the number of resistant mutations to protease inhibitors, or a loss of viral fitness significantly correlates with the level of phenotypic maximal... Read more »
Connect With Others

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...convincing our local doc (conservative infectious disease specialist, with limited knowledge of Hemophilia) that saving the new HIV meds/classes for future use will not matter if no adherence to present classes (PIs) is possible, and Sean loses... Read more »

The Advocate's Article on Abbott's Price Gouging

Posted by BabyPeanut
...people, said company spokeswoman Laureen Cassidy, who noted that Norvir is still priced at less than half the cost of other protease inhibitors. AIDS caregivers and activists reacted with alarm to the price increase, saying it could... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »