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How Do Antiretroviral Drugs Control The Virus

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AIDS InfoNet

Other Antiretroviral Drugs in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Integrase Inhibitors After HIV's genetic code is changed from a single strand to a double strand by the reverse transcriptase enzyme, it gets inserted (integrated) into the genetic code of the infected cell. Then the HIV genetic code gets "read," producing new viruses. Scientists hope that integration will be another point in the HIV life...
Ask the Experts

Virus under control; but Neuropathy making life miserable..

I've been living with HIV since 1986 and have the virus at present undetectable and T-Cell count of 560...My Doc has tried everything imaginable, even going to Holland for a sugar cane medication which failed...I'm currently sleeping only...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
It is useful to begin with the composition of your current HAART regimen. If you are on any medications that are neurotoxic, they should be stopped or changed. The usual suspects causing or perpetuating neuropathy are d4T (Zerit) and ddI (Videx).... Read more »

Virus under control; but Neuropathy making life miserable..

I've been living with HIV since 1986 and have the virus at present undetectable and T-Cell count of 560... My Doc has tried everything imaginable, even going to Holland for a sugar cane medication which failed...I'm currently sleeping only...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
I'm sorry to hear about your problem which, as you say, seems to affect a large number of people with HIV.I would first make sure that there is nothing else going on, such as a vitamin deficiency, a nerve impingement, etc...I would guess that... Read more »

Can lipodystrophy be reversed even with drug resistant virus?

Hi Gerald,I am a long-term HAART patient w/ a very resistant strain of HIV. I have been on just about everything! I am currently on Invirase,Kaletra,Trizivir & Resscriptor for approx. 20 months. The good news....for me....my CD-4 and V.L. are...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Hello and thanks for posting. Lipodystrophy does tend to reverse after the offending agent is stopped. Since you have a resistant strain of HIV your situation is more challenging. As a generalization, protease inhibitors have been linked to... Read more »

Viral suppression-Virus strength & Drug holiday

First of all, I'd like to thank you for all the insight in this column. Now, for my questions. Here is my history. I've been on HAART for 8 years. My highest VL was 600,000 and lowest CD4 450. My current regimen is Trizivir, Kaletra, and...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Lots of good questions for which we don't have great answers. Stopping treatment when using a long acting drug with a olow threshold for resistance (such as Sustiva) may predispose to resistance (some suggest stopping the Sustiva a week before... Read more »
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"Positive living" eclipsed by ARV (Antiretroviral

Posted by bradford, 1 Reply
"Positive living" eclipsed by ARV (Antiretroviral) drive

Originally, it seemingly appeared that anyone infected with HIV would progress to disease and die. This has long since been realized to no longer be true. We have individuals all over the... Read more »

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies
WASHINGTON, June 23 (Reuters) - U.S. health officials on Friday approved the use of a new HIV drug, made by Johnson & Johnson <JNJ.N>, in combination with related therapies to help treat patients who do not first improve with other... Read more »