How Do I Avoid Mitochondrial Toxicity

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...

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MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Your vitamin regimen seems reasonable under the circumstances. I am not aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of... Read more »

Mitochondrial toxicity

Hi Dr. henry... thanks for your helpful answers. I was under the impression that sustiva/truvada was a very well regarded option for first line treatment, but you mentioned mitochondrial toxicity as a possible side effect. How common is this and...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The rate at which components of the lipodystrophy syndrome develop on some of the newer NRTI combinations (FTC/tenofovir and 3TC/abacavir) seems to be slower that with AZT or D4T combinations (usually with 3TC). Long-term data and independent... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...

Response from Alvan Fisher, M.D.

Brown University School of Medicine

No, not routinely.Alvan Fisher, M.D.... Read more »

mitochondrial toxicity

I've been hearing a lot lately about mitochondrial toxicity and I know one of the most common signs of MT is muscle weakness. I'm 52 and have been positive for around 10 years. My viral load is 15,000 and my t-cell count 450. I'm not...

Response from Thomas N. Kakuda, Pharm.D.

University of Minnesota

Gary,Dysfunctional mitochondria in the muscles can lead to a condition known as "mitochondrial myopathy" which manifests itself as muscle weakness and fatigue. The famous cyclist Greg LeMond retired in 1994 due to this disease.... Read more »

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