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How Do I Avoid Mitochondrial Toxicity

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AIDS InfoNet

Mitochondrial Toxicity

...muscle weakness in people taking AZT. It is probably the cause of "fatty liver" (hepatic steatosis) and high levels of lactic acid that can be caused by all of the nukes. Unfortunately, there is very little research on how much mitochondrial damage each ARV causes to different parts of the body. We also don't know which combinations of drugs cause the most MT. Researchers know how to measure the number of mitochondria in different cells,...
Ask the Experts

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of dietary recommendations in that setting please post! KH Read more »

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been feeling...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on Truvada + Sustiva has been low (<... Read more »

mitochondrial toxicity

if it is thought that some nukes cause mitochondrial toxicities/deficiencies. can these problems interfere with the muscles ability for strenght and growth, ie. the ability to weight train?reason being is that I have had extensive fat loss on my...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There have been some reports of impaired/slowed muscle recovery in the setting of mitochondrial toxicity. In addition, I have cared for some patients who report and have exhibited that phenomenon. It seems to be variable and is often Read more »

Mitochondrial toxicity

Hi Dr. henry... thanks for your helpful answers. I was under the impression that sustiva/truvada was a very well regarded option for first line treatment, but you mentioned mitochondrial toxicity as a possible side effect. How common is this and...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The rate at which components of the lipodystrophy syndrome develop on some of the newer NRTI combinations (FTC/tenofovir and 3TC/abacavir) seems to be slower that with AZT or D4T combinations (usually with 3TC). Long-term data and independent... Read more »
Articles
The Body

The Dangers of Mitochondrial Toxicity: An Update From the 1st International Workshop on HIV & Aging

...the nucleoside analog class of antiretrovirals, which includes Retrovir (zidovudine, AZT) and Zerit (stavudine, d4T), cause mitochondrial toxicity that is associated with subcutaneous fat loss (lipoatrophy), muscle weakness (myopathy), and... Read more »
Seattle Treatment Education Project

Mitochondrial Damage

...The topic of mitochondrial damage is gaining more and more press as a potential side effect of anti-HIV medication. Simply put, the mitochondria are the "energy Read more »
Project Inform

Mitochondrial Toxicity and Lactic Acidosis Fact Sheet

...this enzyme synergistically (where 1+1 = more than 2). At least one group of researchers claims d4T is most commonly related to mitochondrial damage in people, though others do not accept this finding. Early results from a small study show that... Read more »
Women Alive

Mitochondrial Toxicity

...gradual break-down of the mitochondria. When the mitochondria stop performing, many illnesses can arise. This is what is called mitochondrial toxicity. Some diseases related to mitochondrial dysfunction are lactic acidosis, neuropathy, muscle... Read more »
Connect With Others

Excessive Mastubation

Posted by Anonymous, 5 Replies
Ever since I found out that I'm poz, I've been spending a lot more time mastubating. Is that normal? Or could it be because of the amount of time I've been spending reading posts about sexual issues? Pleasing myself has become an every day thing... Read more »

Hiding behind HIV

Posted by Magnet, 4 Replies
I write this question in the hope of gaining insight from both HIV positive gay men as well negative men in "magnetic partnerships". I only now discovered this term "magnetic", as it relates to my life! It can no longer be a twist of fate that my... Read more »

can you avoid lipodystrophy?

Posted by hopefulone, 4 Replies
s there a way you can avoid or lesson the impact of lipodystrophy if on atripla? good diet and regular exercise? or regardless of exercise and diet youre going to change? Read more »

A Toxic Combination

Posted by Choosing2Liv, 9 Replies
If my dilemma was: - just dealing with the virus; or - just suffering with the guilt of cheating on my wife; or - just the feelings of rejections by those who said they loved me; or - just the constant blaming, belittlement and bursts of rage... Read more »