Advertisement

The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol

Hiv Thymidine Analogs

Here's a taste of what TheBody.com has to offer on this topic:
Get the Facts
AIDS InfoNet

Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...
Ask the Experts

thymidine associated mutations

Are there any mutations in HIV RT which confer resistance to both of the thymidine nucleoside analogue RTIs (AZT and d4T)? Is the term thymidine associated mutation (TAM) one that has meaning to HIV physicians?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Yes there are. Although AZT specific mutations don't confer resistance to d4T, a mutation at codon 151 along with a couple of others and an insertion of two amino acids at codon 69 among some other changes, confers class resistance to the... Read more »

Why no adenosine analog NRTI?

Sorry if this is a bit off-topic but I was wondering why there is no adenosine analog NRTI available? Was there something about adenosine that made it an undesirable nucleoside to derive an analog of?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
ddI would be considered in this group as the dideoxyinosine is converted to adenosine inside the cell.... Read more »

Think horses not zebras...

Hi Dr. Bob,Hope you're doing well, you're such a specila person. You've used the analogy (title of my post) in the past and I agreeIf you have a headache, it's not automatically a tumor, butWhen so many things line up how can you...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello Huge Fan,You're still chasing a zebra!You've had 65 negative ELISA tests over 27 months! Frevinsakes!!! In addition you've had undetectable NATs, bDNA, PCR RNA, and PCR DNA. Dude, you just can't get any more negative than... Read more »

The medication algorithm

Hi Dr. Holodniy!It's the analogy guy once again! Can you believe it's the end of the year already? I can't! Well, anyway, this time around I had some questions regarding initial labs and which meds are subsequently prescribed.First,...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
The US Department of Health and Human Services has a fabulous expert panel in place that weighs all the evidence from published data to come up with guidelines on when to start HIV meds (based on CD4 count and viral load), and what to start based on... Read more »
Connect With Others

Jellybean Analogy

Posted by Anonymous, 1 Reply
I found once a sheet comparing taking anti-HIV meds to taking different colored jellybeans - for people without HIV to understand how hard it was. It said stuff like "take the blue jellybean half an hour before eating but not with the red jellybean,... Read more »

HIV Dating, HIV Community, HIV Positive Dating, Meet people with HIV, HIV chatting room

Posted by JoJo1234
More and more HIV dating site are created and I recommend HIVromances.com since it own about 730,000 users now. Most of them are verified. It is totally anonymous and free to join Read more »

HIV Dating, HIV Community, HIV Positive Dating, Meet people with HIV, HIV chatting room

Posted by Hneedlove
More and more HIV dating sites are created and I recommend PositiveSingles.com since it own about 730,000 users now. Most of them are verified. It is totally anonymous and free to join.

120,000+ Conversations Per Day
15,000+ Daily Active... Read more »

HIV Dating, HIV Community, HIV Positive Dating, Meet people with HIV, HIV chatting room

Posted by JoJo1234
http://www.PositiveChats.com - The best, largest, completely anonymous and most trusted online dating site for people with HIV / AIDS in the world.

Top Reasons To Join Us:

The Biggest and Best HIV Dating and Support: 700,000+ HIV singles, 15,000+... Read more »