Hiv Thymidine Analogs

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Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...

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thymidine associated mutations

Are there any mutations in HIV RT which confer resistance to both of the thymidine nucleoside analogue RTIs (AZT and d4T)? Is the term thymidine associated mutation (TAM) one that has meaning to HIV physicians?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Yes there are. Although AZT specific mutations don't confer resistance to d4T, a mutation at codon 151 along with a couple of others and an insertion of two amino acids at codon 69 among some other changes, confers class resistance to the... Read more »

Why no adenosine analog NRTI?

Sorry if this is a bit off-topic but I was wondering why there is no adenosine analog NRTI available? Was there something about adenosine that made it an undesirable nucleoside to derive an analog of?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

ddI would be considered in this group as the dideoxyinosine is converted to adenosine inside the cell.... Read more »

How can i regain my lost Fat which occur after i started taking HIV Med

Hi Dr. thank so much for helping and making us understand what we are going through. Especially for us who don't have a professional Dr. on HIV.My question is that after taking HIV Med. for more than a year i start losing my weight badly all my...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hi,Fat loss, lipoatrophy, is a fairly common and very annoying complication of HIV disease. We've learned it can be associated with use of thymidine analog drugs, such as D4T and AZT. Consequently I would avoid these agents. There is no... Read more »

HIV and Hep B correlation?

Dr. DTD-I have read where people with HepB are more suseptible to get HIV. Is this due to the fact they may have a decreased immune system or is it due to the fact they may partake in riskier behaviors? Also, if it is due to a decreased immune...

Response from Douglas T. Dieterich, M.D.

New York University, School of Medicine

It is because of shared risk factors. HBV and HIV are both basically sexually transmitted diseases. HBV does not affect the immune system, however I am becoming increasingly convinced that HCV may indeed affect the immune system. DTD... Read more »

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Jellybean Analogy

Posted by Anonymous, 1 Reply

I found once a sheet comparing taking anti-HIV meds to taking different colored jellybeans - for people without HIV to understand how hard it was. It said stuff like "take the blue jellybean half an hour before eating but not with the red jellybean,... Read more »

Will standrd HIV-2 Detect these?

Posted by Anonymous, 1 Reply

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15242544

AIDS Res Hum Retroviruses. 2004 Jun;20(6):666-72. Related Articles, Links

Identification of a highly divergent HIV type 2 and proposal... Read more »

Living well with HIV

Posted by LondonLad, 5 Replies

I am new to these messageboards and happened to venture on here as I am due to start my meds in the next week or so. Its something that is worrying me a little but I know friends who have been at this milestone before and look back and wonder what... Read more »

HIV1?HIV2?HIV-O?HIV-N?

Posted by Anonymous, 1 Reply

We didn't even know about HIV until the 1980's. So, we invented a HIV1 test, only to find there is a HIV2. So, we invented a HIV2 only to find out there is a HIV-O. Why are we so ignorant to think there couldn't be another strain...for which we... Read more »

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