Hiv Thymidine Analogs

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Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...

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thymidine associated mutations

Are there any mutations in HIV RT which confer resistance to both of the thymidine nucleoside analogue RTIs (AZT and d4T)? Is the term thymidine associated mutation (TAM) one that has meaning to HIV physicians?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Yes there are. Although AZT specific mutations don't confer resistance to d4T, a mutation at codon 151 along with a couple of others and an insertion of two amino acids at codon 69 among some other changes, confers class resistance to the... Read more »

Why no adenosine analog NRTI?

Sorry if this is a bit off-topic but I was wondering why there is no adenosine analog NRTI available? Was there something about adenosine that made it an undesirable nucleoside to derive an analog of?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

ddI would be considered in this group as the dideoxyinosine is converted to adenosine inside the cell.... Read more »

Think horses not zebras...

Hi Dr. Bob,Hope you're doing well, you're such a specila person. You've used the analogy (title of my post) in the past and I agreeIf you have a headache, it's not automatically a tumor, butWhen so many things line up how can you...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello Huge Fan,You're still chasing a zebra!You've had 65 negative ELISA tests over 27 months! Frevinsakes!!! In addition you've had undetectable NATs, bDNA, PCR RNA, and PCR DNA. Dude, you just can't get any more negative than... Read more »

HBV, HCV, HIV

Dear DTD,I was asking you a question two weeks ago. Perhaps you did not get my question so I ask you again. What I wanted to know is this: Say there is an object that has so little blood on it that you cant see it with the naked eye. If you now get...

Response from Douglas T. Dieterich, M.D.

New York University, School of Medicine

Never impossible, but about as likely as geting hit by a meteorite! Forget it!DTD... Read more »

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Jellybean Analogy

Posted by Anonymous, 1 Reply

I found once a sheet comparing taking anti-HIV meds to taking different colored jellybeans - for people without HIV to understand how hard it was. It said stuff like "take the blue jellybean half an hour before eating but not with the red jellybean,... Read more »

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