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Hiv Reverse Transcriptase

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AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 460 : attachment and fusion inhibitors Fact Sheet 470 : new classes of antiretroviral drugs Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. ...
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TESTING for reverse transcriptase

Dear Dr. Conway, As this is a forum for managing side effects of HIV treatment, I was wondering if you can just very quickly answer a question. How do you test for the reverse transcriptase enzyme. Where can you go to be tested for it?Thanks a...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
This is an experimental test done for research purposes only, in which a DNA/RNA hetrodimer is exposed to the test sample in question (plasma or cell extract) to see if it acts to extend the DNA (a task that can only be accomplished by a reverse... Read more »

Testing for Reverse Transcriptase

Dear Dr. Holodniy, I have a question regarding the enzyme reverse transcriptase. Is the enzyme present in all HIV infections, as well as other retroviruses. If so, how do you test for the enzyme in a patient?Thanks a lot....
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
THe enzyme is present in all HIV infections and other retroviral infections. We don't normally test for the RT or RT activity directly. A western blot test, will detect antibodies that have developed against the RT part of the virus. A new test... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can then get inside the cell nucleus and become incorporated into the human cell DNA. The enzyme takes... Read more »

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Non-nucleoside RT... Read more »
Connect With Others

reversing lipodystrophy....

Posted by Anonymous, 1 Reply
Positive since 2003 full blown aids. Was on Kaletra and combivir. Reached non-detectable, and cd4 rising as expected. Into 3rd year noticing increase in truncal girth. Waist went from 27in. to 32in of hard solid protruding fat. Arms, legs, face... Read more »

HIV-1? HIV-2? HIV-O?

Posted by Anonymous, 6 Replies
We didn't even know about HIV until the 1980's. So, we invented a HIV1 test, only to find there is a HIV2. So, we invented a HIV2 only to find out there is a HIV-O. Why are we so ignorant to think there couldn't be another strain...for which we... Read more »

< 400 copies of HIV RNA per 1 ml of plasma (????)

Posted by Anonymous

PCR RNA @ 28 Days...

Is this a woo-hoo ?
Read more »

how accurate is hiv dna test

Posted by gpboy, 1 Reply
i have given hiv dna pcr test on 9th day after probable exposure.

i am waiting for the results in next two days. can any one say how much i can trust this test results? Read more »