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Spotlight Series: HIV Stigma and Discrimination

Hiv Reverse Transcriptase Inhibitors

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

... Non-Nucleoside Reverse Transcriptase Inhibitors NNRTIs in Development NNRTIs No Longer in Development Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact
Ask the Experts

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Read more »

Aging and HIV

Read your blog on this topic. Anything new to report on getting old? Advanced aging? HIV sure knows how to hurt a guy. By the way what's the latest, is it the virus or is it the drugs that's forcing us into old folks homes in the prime of our lives?...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...cellular level for the accelerated aging problems seen in HIVers.Some evidence suggests that cumulative exposure to HIV nucleoside reverse transcriptase inhibitors (like d4T, AZT, etc.) is associated with irreversible damage to the mitochondria... Read more »

My chances of reshaping my body with hiv?

I've been positive since 1988, presently on kaletra and epzicom. What can I do to lose extra fat? Don't want to look sick but can't be overweight and uncomfortable either
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...that have shown improvement in lipohypertrophy when protease inhibitors (Kaletra in your case) are switched for non-nucleoside reverse transcriptase inhibitors (NNRTIs). If you have been on treatment with this class in the past and have virus... Read more »


Dr. Keith Henry:Can HIV medications cause irreparable damage to the mitochondria, which in turn can lead to the developement of cancer in the lymphatic system?
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...HIV medications (particularly some of the nucleoside reverse transcriptase inhibitors-NRTIs- such as D4T or AZT) can cause mitochondrial dysfunction/damage that is reversible in the vast majority of cases. There Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) Clinical Trials of HIV-1 Protease Inhibitors (Session 41) Immune Reconstitution (Session 45) Treatment of Primary Infection (Session 47)

... Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) START Observational Study: Longitudinal Follow-Up of Virologic and Immunologic Responses in START I and START Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors

...200mg BID NVP) to a protease-inhibitor-containing regimen (nelfinavir 750mg TID NFV) each given with the background nucleoside reverse transcriptase inhibitor Combivir (ZDV 300mg/3TC 150mg BID). The study enrolled 142 HIV-infected patients... Read more »
The Body PRO

New Insights Into Mechanisms of HIV-1 Resistance to Reverse Transcriptase Inhibitors (Plenary Session 22)

...normal building blocks required for HIV RNA to become DNA are linked together by specific chemical interactions. Nucleoside reverse transcriptase inhibitors (NRTIs) inhibit HIV replication through a process known as chain termination. NRTIs are... Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors

...Hammer, S. Liou, R. Bosch, and D. Katzenstein View the original abstract We try to use as few agents as possible to suppress HIV in order to preserve agents for future use and limit toxicity. Current thought involves the use of three or... Read more »
Connect With Others

Should i Start medication???

Posted by coconyc, 3 Replies
Hi im Coco from nyc I though the benefit or getting tested its to find out the virus in a early time so u can get a good treatment that prolong ur life in a better condition, i got my first results a month ago and i got CD4:276 and VL: 3616, so my... Read more »

DDC Bites the Dust

Posted by Bear60, 1 Reply
...Pharmaceuticals announced that it will be ending the sale and distribution of Hivid (zalcitabine, also known as ddC), a nucleoside reverse transcriptase inhibitor (NRTI) originally approved in 1992. The tablets will not be available in U.S.... Read more »

Failed a Urinalysis

Posted by SDNavy, 4 Replies
Hey, I recently had a random urinalysis at work, and come to find out I failed it. I do not do illegal drugs, but I do take the meds my doctor have prescribed to me. I am getting mixed answers from various doctors as to wether or not my meds can... Read more »

Vasculitis and HIV

Posted by Anonymous, 3 Replies
...Does anyone know about vasculitis and HIV? Read more »