Hiv Resistance Genetic Mutation

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HIV Drug Resistance

Table of Contents What Is Resistance? What Causes Resistance? Cross-Resistance and Sequencing How Do I Know if I Have Drug Resistance? Resistance Testing Avoiding Resistance What Is Resistance? HIV drugs are designed to keep your viral loadunder control by preventing the virus from reproducing (or making copies ofitself). Sometimes HIV is able to overcome the effects of a drug and keepreproducing anyway. When this happens,...

Ask the Experts

Which HIV-1 Drug Resistance Mutations Are Common in Clinical Practice?

I know most mutations are polymorphisms...but which are most common and have significance for treatment?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Go to: http://www.iasusa.org, and on the left side tabs, go to resistance mutations. That will lead to a table that shows all the HIV medication associated mutations.... Read more »

HIV/AIDS Resistance Gene (DELTA 32 mutation)

In my contemporary biology class, we heard about a gene found in males of Northern European descent that has HIV/AIDS resistant properties. My family is very Irish (my last name is Sullivan), and I was wondering not only if this is true, but if...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hi,I believe what you are referring to is the delta 32 gene mutation. See below.Dr. BobHad unprotected sex with a guy who has ccr5 delta 32 (DELTA 32)Oct 13, 2008 Last night I had unprotected sex with a guy who claims that he has ccr5 delta 32 and... Read more »

G333D multidrug-resistance associated mutation?

Several reports have shown that mutations in codon 333 of the RT gene is associated to AZT plus 3TC resistance. However, the same works also showed that viral variants lacking that mutation were resistant to AZT plus 3TC. In addition, the presence...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Great question!! Remember that most all of the genotypic resistance reports are from population based sequencing assays. HIV exists as a group of strains within the plasma. Population sequencing can only determine if a mutation is present among the... Read more »

mutations and resistance

Dear Dr. Young, I have written you before regarding other issues and you seem to have a wonderful way of explaining & putting things into perspective. I hope you can do the same in this situation. As mentioned before, I have a wonderful...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post and kind words.I'm happy to hear that you've linked up with our good friend (and ace HIV doc), Dr. DeJesus. I agree with the notion that this isn't yet the time to start medications and concur with obtaining drug... Read more »

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Connect With Others

mutated hiv

Posted by Anonymous, 1 Reply

Recently Is that true the fact that exist mutated hiv(can't detect Antibody test)?
If the fact's true.. How should we do?

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mutation

Posted by drnsee, 3 Replies

I'm aware that the HIV virus itself may mutate over time. However, my partner who has had HIV twice as long as I have heard that it actually mutates your own [human] DNA. That it integrates into your system so much that this happens over time.

I'm... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

Mutate

Posted by Anonymous, 1 Reply

I was just wondering if anyone knows what subtypes are know to be circulating in the US and whats there prevelance? Also anyone know why all mutations seem to occur outside the US. Why dont mutations occur in America?

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