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Hiv Protease Structure

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AIDS InfoNet

Other Antiretroviral Drugs in Development

...Phase III trials. It does not require boosting. S/GSK 1265744 by ViiV Healthcare is an integrase inhibitor. It is in a Phase IIa trial. Maturation Inhibitors A new type of drug inhibits the development of HIV's internal structures in a new virus. The first "maturation inhibitor" was bevirimat by Myriad Pharmaceuticals. A backup compound was also in development. Early results showed good antiretroviral activity and tolerability. However,...
Ask the Experts

Is this agent effective against hiv-2?

Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.Beaulieu PL, Wernic D, Abraham A, Anderson PC, Bogri T, Bousquet Y, Croteau G, Guse I, Lamarre D, Liard F, Paris W, Thibeault D, Pav S, Tong L.Bio-Mega Research Division,...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...inhibitors have activity against HIV-2. I would suspect that this compound, does as well-- but it is a very long way from an X-ray structure to having a safe, effective and well tolerated drug. BY Read more »

Stocrin and Babies (Safety and Toxicity of Anti-HIV Medications During Pregnancy, 2009)

Hi,Thanks for all the advise so far.I am 34yr female and positive for the last 11yrs, am considerng having a baby next year.I have been on stocrin and truvada for the last two yrs.I know stocrin is not compatable with pregnancy so I need advice as...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...DNA. In utero: the time an unborn baby is in its mother's uterus. Mitochondrial toxicity: damage to the mitochondria (rod-like structures that serve as a cell's powerhouse) that can cause problems in the heart, nerves, muscles, pancreas, kidneys,... Read more »


Hi,First I want to say what a valuable and informative resource this website is. My question is this: I would like to take a brief, supervised treatment interruption of approx. 6 weeks in order to travel without having to bring my HAART meds with...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...efavirenz and which is often better tolerated.Good luck and have a great vacation!Dr. BobWhat's the worst that could happen? (STRUCTURED TREATMENT INTERUPRTIONS) (STRATEGIC TREATMENT INTERUPRTIONS)Jul 10, 2008 Dear Dr. Bob, I think my question is... Read more »

Pontential new target for HIV MEDS with A3G

Hi Dr Keith, thank you for your time and work you put into helping people with hiv,What can you let us know about A3G and maybe changing the way we compat hiv..thank you once again Anton Scientists continue to unravel a potential new target for HIV...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
This is a promising new target for anti-HIV drug development but there is no A3G-related candidate drug currently under clinical (human) study that would likely be avalable in the near future. Current therapy available in resource weathly areas... Read more »
Canadian AIDS Treatment Information Exchange

Emerging HCV Therapies: Possible Interactions With HIV Drugs

...serine-containing enzymes, production of HCV falls. For the treatment of HIV infection, sometimes a class of drugs called HIV protease inhibitors is used as part of combination therapy. These drugs work by targeting enzymes containing the... Read more »
Merck & Co., Inc.

Vaccination and Enrollment Are Discontinued in Phase II Trials of Merck's Investigational HIV Vaccine Candidate

...years and continue today; our HIV research program began in 1986. Merck scientists were the first to characterize the role of HIV protease in the HIV life cycle and to publish the crystal structure of the HIV protease enzyme, which helped the... Read more »
San Francisco General Hospital

How the Protease Inhibitors Work

...regulatory gene products. Within the pol region of the virion's genetic structure (Figure 1, below), researchers found codons for HIV protease, reverse transcriptase, and integrase (Figure 1, central blue band), which are essential to the... Read more »
Gay Men's Health Crisis

Debate Widens Over Protease Inhibitor Side Effects

...Dr. Cooper presented the theory at an oral session in Geneva (abstract 176). According to their research, the region of the HIV protease enzyme to which protease inhibitors bind is structurally similar to regions on two human proteins that... Read more »
Connect With Others

Use your computer to "Fight AIDS at Home"

Posted by nnhood
...participate in. The AIDS project is using computers around the globe to crunch numbers in designing meds to attack the HIV cell structure and protease. There is a tiny program to download and it will talk with your online account to see what... Read more »

Am I Infected

Posted by delhiguy, 3 Replies
I am 30 YO guy. Worried that I may have got infected. I met this friend of mine on 5th of Dec 2010 which was just a causual meeting after 5 years. After having drinks she started touching me and I got aroused and we end up mating. While in act, she... Read more »

Im new and want friends!=)

Posted by chula93, 1 Reply
hey! i am new here. I have had HIV all my life. i was born with it. Anyway, i thought it would be nice to talk to other people. Dame un mesaje si tu quieres=) Read more »


Posted by LostNconfused, 5 Replies
I tested positive 3 days before Christmas and I think I am still numb to the fact. I haven't told any friends or family because I really don't know how and most are judgemental and I'm sure will walk away. But I guess if they do, then I didn't need... Read more »