Hiv Protease Inhibitor Resistance

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Articles

Tibotec Experimental Protease Inhibitor Successfully Lowers Viral Loads of HIV Patients With Drug Resistance, Study Shows

A protease inhibitor produced by the Belgian pharmaceutical company Tibotec , a unit of Johnson & Johnson, has shown success treating HIV-positive people who are resistant to other medications, researchers at the 12th Conference on Retroviruses... Read more »

European Commission Approves Boehringer Ingelheim's Protease Inhibitor Aptivus to Treat Drug-Resistant HIV

The European Commission has approved Boehringer Ingelheim 's protease inhibitor Aptivus to be used in combination with Abbott Laboratories ' Norvir for HIV/AIDS patients who have become resistant to other drugs, Boehringer said on Wednesday,... Read more »

FDA Approves Boehringer Ingelheim's Protease Inhibitor Aptivus to Treat Drug-Resistant HIV

FDA on Wednesday approved Boehringer Ingelheim 's protease inhibitor Aptivus to be used in combination with Abbott Laboratories ' Norvir for HIV/AIDS patients who have become resistant to other drugs, Reuters reports. Boehringer on Wednesday said... Read more »

Ask the Experts

cryptococcal meningitis Resistant to Protease Inhibitors

What would you advise a patient with CD4s of 8, a Viral Load over 100,000, off therapy for six months because of wasting that may have been caused by meds?weight returned from about 129lbs. to 160lb after stopping Crixivan, Kaletra, Combivir,...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Clearly a tough situation. Maximizing nutrition, maintain good body weight (check testosterone levels),prevention of other opportunistic infections, aggressive use of amphotericin--those treatments can often maintain a person's health. There... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...

Response from Eric Daar, M.D.

UCLA School of Medicine

The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

Protease Inhibitors and Living with HIV/AIDS

Just wondering, is there a train of thought that protease inhibitors may ultimately prevent the possibility of AIDS occuring and basically have people living with HIV for an entire lifetime? Upon initially beginning treatment for hiv is it possible...

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program

Thank you for your questions.When it comes to the protease inhibitors and other antiviral therapies, there is good news and bad news.The good news:1) Treatments have been shown to significantly improve the quantity of a persons life. People taking... Read more »

New Protease Inhibitor

Hello doc. Are you aware of a new protease inhibitor from Bristol Myers called BMS-232632? It's supposedly more potent than any known protease inhibitor, but I don't have any information on the current phase it's in......

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

BMS-232632 is a new protease inhibitor that is being developed by Bristol Myers Squibb. Luckily, it is about due to get a real name. The studies presented so far have demonstrated that it has a long half life and probably can be used as a once a day... Read more »

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Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

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