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Hiv Protease Inhibitor Mechanism Of Action

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
Ask the Experts

mechanism of action of fusion inhibitors

how do fusion inhibitor act to treat HIV...
Don Kurtyka, ARNP

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine
There's a ton of information on thebody.com that describes how fusion inhibitors work. You might want to also check out www.fuzeon.com.If you're more into graphics, check out the video link in this message! It's very cool. <a... Read more »

drug-protease mechanism

What are the key biochemical features of the drug-protein interaction that allows it to function as a protease inhibitor? ...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
They bind to the active site of the protease enzyme so the HIV polyprotein is not allowed to enter the active site and be cut into smaller pieces by the protease.... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

Protease Inhibitors and Elevated Cholesterol & Triglycerides

I have been in 'drug failure' until taking a PI regimen consisting of ABT-378, Amprenavir, Crixivan & Combivir. Since starting this protocol last March, I have now undetectable levels of HIV for the first time since diagnosed with AIDS...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Wow -- what a story! I agree that your current regimen is doing very good job from HIV perspective and that the high levels of the PIs achieved with use of ritonavir is key to that but also a likely culprit for the high lipids. Use of fenofibrate... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »