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Hiv Protease Active Site

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Get the Facts
AIDS InfoNet

Drug Use and HIV

How Does Drug Use Relate to HIV? Injection and Infection Access to Clean Needles Drug Use and Unsafe Sex Medications and Drugs The Bottom Line How Does Drug Use Relate to HIV? Drug and alcohol use is a major factor in the spread of HIV infection. Shared equipment for using drugs can carry HIV and hepatitis, and drug and alcohol use is linked with unsafe sexual activity. Drug and alcohol use can also be dangerous for people...
Ask the Experts

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops Read more »

drug-protease mechanism

What are the key biochemical features of the drug-protein interaction that allows it to function as a protease inhibitor?
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...They bind to the active site of the protease enzyme so the HIV polyprotein is not allowed to enter the active site and be cut into smaller pieces by the protease. Read more »

dietary protease vs HIV protease

My mother who is a dietician feels my regimen of Kaletra, Invirase and Truvada is interfering with fat absorption. She feels this is why PI's seem to result in smelly or loose stools. Her solution, dietary enzymes which contain the...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...pancreatic problems take those replacement enzymes with benefit and no apparent interference with absorption/activity of their HIV protease inhibitors (completely different target of action). There is no clear data that the GI problems seen with... Read more »

New Protease Inhibitor

Hello doc. Are you aware of a new protease inhibitor from Bristol Myers called BMS-232632? It's supposedly more potent than any known protease inhibitor, but I don't have any information on the current phase it's in...
Andrew T. Pavia, M.D.

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine
BMS-232632 is a new protease inhibitor that is being developed by Bristol Myers Squibb. Luckily, it is about due to get a real name. The studies presented so far have demonstrated that it has a long half life and probably can be used as a once a day... Read more »
Articles
San Francisco General Hospital

How the Protease Inhibitors Work

...structure had finally been identified, however, researchers were able to begin designing compounds that specifically targeted the active site of the HIV protease. Protease enzymes are proteins that cut other proteins at highly specific locations.... Read more »
University of California-San Francisco

UCSF Researchers Identify New Drug Target for Kaposi's Sarcoma

...Chemical Biology" web site and can be found at www.nature.com/nchembio/index.html . Most current antiviral drugs target the active sites of viral proteins, where enzymes and receptors work in a lock-and-key approach to either activate or... Read more »
Project Inform

IRIS: A Concern for People Starting HIV Therapy

Introduction What Is Inflammation? What Is IRIS? How Is It Diagnosed? Who Is at Risk? What Are the Symptoms? How Do You Treat IRIS? What Can Help to Ask My Doctor? Special Concerns for People Living With HIV Special... Read more »
Test Positive Aware Network

Fuzeon

Common Name: enfuvirtide or T-20 Brand Name: Fuzeon Class: HIV fusion inhibitor (a type of entry inhibitor) Standard dose: One subcutaneous (under the skin) injection of 90 mg (1 ml) twice daily (every 12 hours) into the upper... Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting. I have just spoken to my son again. He was finally able to convince... Read more »

Am I Infected

Posted by delhiguy, 3 Replies
I am 30 YO guy. Worried that I may have got infected. I met this friend of mine on 5th of Dec 2010 which was just a causual meeting after 5 years. After having drinks she started touching me and I got aroused and we end up mating. While in act, she... Read more »

Lost

Posted by LostNconfused, 5 Replies
I tested positive 3 days before Christmas and I think I am still numb to the fact. I haven't told any friends or family because I really don't know how and most are judgemental and I'm sure will walk away. But I guess if they do, then I didn't need... Read more »

Excessive Mastubation

Posted by Anonymous, 5 Replies
Ever since I found out that I'm poz, I've been spending a lot more time mastubating. Is that normal? Or could it be because of the amount of time I've been spending reading posts about sexual issues? Pleasing myself has become an every day thing... Read more »