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Hiv Protease Active Site

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Ask the Experts

dietary protease vs HIV protease

My mother who is a dietician feels my regimen of Kaletra, Invirase and Truvada is interfering with fat absorption. She feels this is why PI's seem to result in smelly or loose stools. Her solution, dietary enzymes which contain the...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
What you are describing is a combination of enzymes produced by the pancrease to facilitate digestion and absorption of food from the gut. If there is pancreatic insufficiency then those enzymes are given in pill form and that is often helpful. I... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial... Read more »

drug-protease mechanism

What are the key biochemical features of the drug-protein interaction that allows it to function as... Read more »
Articles
San Francisco AIDS Foundation

Tipranavir: The First Nonpeptidic Protease Inhibitor

Introduction Recent Data BI 1182.2 BI 1182.52 Resistance Profile Drug Interactions RESIST Selected Sources Introduction Resistance to anti-HIV medications is an ongoing dilemma. A recent study in 16 European countries and Israel found... Read more »
San Francisco General Hospital

How the Protease Inhibitors Work

The protease inhibitors represent one of the best examples of the application of basic scientific knowledge to rational drug design. Relatively soon after the discovery of HIV, researchers were able to elucidate the genetic structure of the virus... Read more »
San Francisco AIDS Foundation

Dual Protease Inhibitors Gain Ground

Adding Ritonavir to Boost Saquinavir Once-Daily and Twice-Daily Regimens with Indinavir Plus Ritonavir Kaletra: Abbott Joins the Bandwagon Bringing Amprenavir Back from the Edge What Is the Real Benefit? Selected Sources The past couple of... Read more »
U.S. Centers for Disease Control and Prevention

Current Use of HIV Protease Inhibitors Not Linked to Sudden Death

Current or recent use (within a year) of HIV protease inhibitors was not associated with a composite endpoint of sudden death or first non-hemorrhagic stroke, a new study suggests. However, a secondary analysis found such an association with... Read more »
Connect With Others

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous, 2 Replies
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »

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