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Hiv Polyprotein

Here's a taste of what has to offer on this topic:

HIV Antiretroviral Agents in Development

Need CME/CE credit? You can get credit for this article on The Body Pro . /table for CME link --> Introduction NRTIs Protease Inhibitors NNRTIs Entry Inhibitors Integrase Inhibitors Maturation Inhibitors Conclusion References ... Read more »
San Francisco General Hospital

How the Protease Inhibitors Work

The protease inhibitors represent one of the best examples of the application of basic scientific knowledge to rational drug design. Relatively soon after the discovery of HIV, researchers were able to elucidate the genetic structure of the virus... Read more »
Gay Men's Health Crisis

Antiretroviral Medications in the Pipeline

Over two years ago, four new antiretrovirals were approved: Two of these introduced new classes of therapy, and two others provided new hope for already resistant viruses. These were added to the 20 existing antiretrovirals and have provided even... Read more »
Ask the Experts

drug-protease mechanism

What are the key biochemical features of the drug-protein interaction that allows it to function as a protease inhibitor? ...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
They bind to the active site of the protease enzyme so the HIV polyprotein is not allowed to enter the active site and be cut into smaller pieces by the protease.... Read more »

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »